DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and aldh16a1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001039089.1	Gene:	aldh16a1 / 733905	XenbaseID:	XB-GENE-5726619	Length:	829	Species:	Xenopus tropicalis

Alignment Length:	465	Identity:	172/465 - (36%)
Similarity:	270/465 - (58%)	Gaps:	18/465 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTAKDRSNLL 97
            :||.|: ....:.|:..:|||.|..:.........|.:.|:.||::|:||  |..|....|:..|
Frog    46 IDGKWL-KPEGRNTYTTKNPATGEALASTVQGEEEDVETAVKAARKAFES--WSKLPCHVRARYL 107

  Fly    98 KKWHKLIEQHSQEIAEIMTAESGKPINESKG-EVAYGNAFVEWFAEEARRIYGEIVPSASPNREI 161
            ....:.:::|.:.::.|.:.::||||.|::. :|..          ..|..|.....:...:.|:
Frog   108 YSIARTVQKHQRLLSVIESMDNGKPIREARDCDVPL----------VVRHFYHHAGWAQLRDTEM 162

  Fly   162 IVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLAVDAGIPKGV 226
            ...| |:||.|.|.|||||:.::|.|...|||.|.|||:||:..|.||||.:|::..:||:|.||
Frog   163 NGWK-PLGVIAAIVPWNFPLMLLTWKICPALAMGNTVVLKPATYTRLTALLLAEICAEAGLPPGV 226

  Fly   227 INVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSADGIKRICLELGGNAPFIVFDSAD 291
            .||||.|.|  .|......|||..::||||||||:.|.:.:|...|::.|||||.:||||||::|
Frog   227 FNVVTGNGA--FGGKLADHPDVDKVAFTGSTEVGRTLRKATAGTGKKLSLELGGKSPFIVFDTSD 289

  Fly   292 IEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQGCDVQIGPLINE 356
            ::.||:|.:.:.:.|.||.|.:.:|..:|:|:.:..:.:||:|:..|::||.....:.:|.|::|
Frog   290 LDSAVEGIVDAIWFNQGQVCSAGSRLLMQESIAEDLIRRLKQRMSHLRLGDSLDKAIDVGALVDE 354

  Fly   357 MQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVFGPVVSIIRFR 421
            .|...:..|||:|:::.|::.....|:|.|| |||.||::|.|..:::...||:||||:..:.||
Frog   355 TQKKTIEEFVEEAQAEGADVFQSPGPIPKKG-LFYPPTLITGVNTTSRCVREEIFGPVLVAMTFR 418

  Fly   422 DEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAPFGGVKESGVGRE 486
            ..:||:...|:|..|||...::|||.....||..::.|.|.||...:..|.|.|||.||||.||:
Frog   419 TAKEAIALGNNTPYGLAASVWTENLPLALEVAISIKAGTVWVNGHNMFDAAAGFGGYKESGFGRD 483

  Fly   487 GSKHGIDDYV 496
            |.|.|:.:||
Frog   484 GGKEGLYEYV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	168/449 (37%)
aldh16a1	NP_001039089.1	ALDH_F16	21..500	CDD:143429	172/465 (37%)
aldh16a1	NP_001039089.1	ALDH-SF	572..>788	CDD:299846
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910