DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and Aldh16a1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_666066.1	Gene:	Aldh16a1 / 69748	MGIID:	1916998	Length:	802	Species:	Mus musculus

Alignment Length:	501	Identity:	142/501 - (28%)
Similarity:	234/501 - (46%)	Gaps:	54/501 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AWVDSSNAKATFEV---------RNPA------NGAVIGKVPNMTVADAQKAIDAAKQAYESKEW 85
            ||:|:.|......|         ||||      .|..:.........|...|::|||.|:  |.|
Mouse    31 AWLDTHNRLLGHHVNGMWLKPEHRNPAPCQDPITGENLASCLQAEAEDIAAAVEAAKIAF--KAW 93

  Fly    86 RSLTAKDRSNLLKKWHKLIEQHSQEIAEIMTAESGKPINESK-GEVAYGNAFVEWFAEEARRIYG 149
            ..|....|...|.:..|::::|.:.:..:.:..:|:.:.|.: |:|......:::.|.:|.
Mouse    94 SQLPGAARGQHLTRLAKVVQKHQRLLWTLESLVTGRAVREVRDGDVPLAQQLLQYHAVQAH---- 154

  Fly   150 EIVPSASPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVV--VKPSEDTPLTALA 212
                   ...:.:...||:||..||.|..|....:..:...|||.|||||  |.|:..||   |.
Mouse   155 -------AQGDALADWQPVGVIGLILPTPFSFLDMMWRVCPALAMGCTVVALVPPAFPTP---LL 209

  Fly   213 VAKLAVDAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSADGIKRICLE 277
            :|:||.:.|...|::|||.  ..|.:|.:....|.|:.::|.|:.|.|::|.|..|.....:.|.
Mouse   210 LAQLAGELGSFPGILNVVC--GPASLGPVLASQPGVQKVAFCGAVEEGRVLRRTLAGRGAELGLA 272

  Fly   278 LGGNAPFIVFDSADIEKAVDGAMASKF--RNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKI 340
            ||..:..::.||||::.||:|.:.:.:  |:.|     ..|..:|:||:|:.:.:|:.|:..::.
Mouse   273 LGTESLLLLMDSADVDSAVEGVVDAVWSDRSLG-----GLRLLIQESVWDEAMRRLQARMAQIRS 332

  Fly   341 GDGQGCDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQL 405
            |.|....|.:|.. .....:....||::|:|:...:...|. :| ..|.|::|.:|:.:||:|..
Mouse   333 GRGLDGAVDMGAR-GAAARDLAQSFVDEAQSQGGQVFQAGD-VP-SSSPFFSPALVSGLPPAAPC 394

  Fly   406 YSEEVFGPVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISA 470
            ...||..|||....||..:||:..||.|.||.:...:||.|.|...:...|:||.|.:|...:..
Mouse   395 AQAEVPWPVVMASPFRTVKEALALANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRD 459

  Fly   471 AEAPFGGVKESGVGREGSKHGIDDYV-------DIKYICMGNLKYD 509
            ...|.||.||||....|...|:.:|:       ...::| .|:.||
Mouse   460 PAVPTGGCKESGSSWHGGPDGLYEYLQPLGTPSQESFLC-ENINYD 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	134/480 (28%)
Aldh16a1	NP_666066.1	ALDH-SF	19..491	CDD:299846	138/485 (28%)
Aldh16a1	NP_666066.1	ALDH-SF	527..>765	CDD:299846
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910