DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and Aldh1l1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_071992.2	Gene:	Aldh1l1 / 64392	RGDID:	621294	Length:	902	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	177/476 - (37%)
Similarity:	282/476 - (59%)	Gaps:	10/476 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTAKDRSNLL 97
            :.|.:||:..:| |:...||.:|:||.:|....|:|..||:.|||:|:|:..|..:.|:||..||
  Rat   426 IGGEFVDAEGSK-TYNTINPTDGSVICQVSLAQVSDVDKAVAAAKEAFENGLWGKINARDRGRLL 489

  Fly    98 KKWHKLIEQHSQEIAEIMTAESGKPINES-KGEVAYGNAFVEWFAEEARRIYGEIVP--SASPNR 159
            .:...::|||.:|:|.|...::|.....: |..|........:||....:|.|..:|  .|.|||
  Rat   490 YRLADVMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGATIPINQARPNR 554

  Fly   160 EI-IVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLAVDAGIP 223
            .: :..|:|:||..::.|||:|:.|::.|..|.||||.|||:||::.||||||..|:|.:.||||
  Rat   555 NLTLTKKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIP 619

  Fly   224 KGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSA-DGIKRICLELGGNAPFIVF 287
            |||:|:: ....:.:|......||||.|.|||||||||.:.::.| ..:|::.|||||.:|.|:|
  Rat   620 KGVVNIL-PGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCALSNVKKVSLELGGKSPLIIF 683

  Fly   288 DSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQGCDVQIGP 352
            ...|:.|||...|:|.|.|.|:.|::|.|.||::|::::||.::.:.||.:|||:....|...||
  Rat   684 ADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEESIHNQFVQKVVEEVEKMKIGNPLERDTNHGP 748

  Fly   353 LINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVFGPVVSI 417
            ..:|....|:..:.:....:.|.::.||..:|..| .|:.||:.|||.....:..||.|||::.|
  Rat   749 QNHEAHLRKLVEYCQRGVKEGATLVCGGNQVPRPG-FFFQPTVFTDVEDHMYIAKEESFGPIMII 812

  Fly   418 IRFRD-EEEAV-KKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAPFGGVKE 480
            .||.| :.:|| .:||.|..|||...::.::.:...|:.:|:.|.|.:|....:...|||||.|:
  Rat   813 SRFADGDVDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFINTYNKTDVAAPFGGFKQ 877

  Fly   481 SGVGREGSKHGIDDYVDIKYI 501
            ||.|::..:..:::|:.||.:
  Rat   878 SGFGKDLGEAALNEYLRIKTV 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	172/460 (37%)
Aldh1l1	NP_071992.2	GART	1..203
		Substrate binding. /evidence=ECO:0000250	88..90
		Aldehyde dehydrogenase	417..902		177/476 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810