DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and Aldh1a3

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_444310.3	Gene:	Aldh1a3 / 56847	MGIID:	1861722	Length:	512	Species:	Mus musculus

Alignment Length:	488	Identity:	177/488 - (36%)
Similarity:	267/488 - (54%)	Gaps:	33/488 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYE-SKEWRSLTAKDR 93
            |..::..|.:|.:.: .|...||:....|.:|......|..||::||:.|:: ...||.|.|..|
Mouse    33 KIFINNDWHESKSGR-KFATYNPSTLEKICEVEEGDKPDVDKAVEAAQAAFQRGSPWRRLDALSR 96

  Fly    94 SNLLKKWHKLIEQHSQEIAEIMTAESGKPINESKGEVAYGNAF----------VEWFAEEARRIY 148
            ..||.:...|:|:....:|.:.|.::|||         :.:||          ..:||..|.:|.
Mouse    97 GQLLHQLADLVERDRAILATLETMDTGKP---------FLHAFFVDLEGCIKTFRYFAGWADKIQ 152

  Fly   149 GEIVPSASPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAV 213
            |..:|: ..|.......:||||...|||||||:.|:..|...||..|.|||:||:|.||||||.:
Mouse   153 GRTIPT-DDNVVCFTRHEPIGVCGAITPWNFPLLMLAWKLAPALCCGNTVVLKPAEQTPLTALYL 216

  Fly   214 AKLAVDAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSA--DGIKRICL 276
            |.|..:.|.|.||:|:| ......:|......|.:..|:||||||||||: |.:|  ..:||:.|
Mouse   217 ASLIKEVGFPPGVVNIV-PGFGPTVGAAISSHPQINKIAFTGSTEVGKLV-REAASRSNLKRVTL 279

  Fly   277 ELGGNAPFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALK-- 339
            ||||..|.||...||::.||:.|....|.|.||.|.:|:|.||::.||.:||   ::.||..|
Mouse   280 ELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYGEFV---RRSVEFAKKR 341

  Fly   340 -IGDGQGCDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSA 403
             :||......:.||.|::.||:|:...:|..:.:.|.:..||..:.|:| ||..||:.:||..:.
Mouse   342 PVGDPFDAKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDRG-LFIKPTVFSDVTDNM 405

  Fly   404 QLYSEEVFGPVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGII 468
            ::..||:||||..|::|::.||.:|:||.|..||....:::||.:..::|..||.|.|.:|....
Mouse   406 RIAKEEIFGPVQPILKFKNLEEVIKRANSTDYGLTAAVFTKNLDKALKLAAALESGTVWINCYNA 470

  Fly   469 SAAEAPFGGVKESGVGREGSKHGIDDYVDIKYI 501
            ..|:|||||.|.||.|||..::.:.:|.::|.:
Mouse   471 FYAQAPFGGFKMSGNGRELGEYALAEYTEVKTV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	173/469 (37%)
Aldh1a3	NP_444310.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
Aldh1a3	NP_444310.3	ALDH_F1AB_F2_RALDH1	26..506	CDD:143459	177/488 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810