DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and ALDH7A1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001173.2	Gene:	ALDH7A1 / 501	HGNCID:	877	Length:	539	Species:	Homo sapiens

Alignment Length:	477	Identity:	139/477 - (29%)
Similarity:	240/477 - (50%)	Gaps:	17/477 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QDKALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTAKD 92
            :::.:.:|:|........|:   .|||...|.:|...:|||.::.:..|::|:  |.|..:.|..
Human    50 ENEGVYNGSWGGRGEVITTY---CPANNEPIARVRQASVADYEETVKKAREAW--KIWADIPAPK 109

  Fly    93 RSNLLKKWHKLIEQHSQEIAEIMTAESGKPINESKGEVAYGNAFVEWFAEEARRIYGEIVPSASP 157
            |..::::....:.:..|.:..:::.|.||.:.|..|||.......::....:|.|.|.|:||...
Human   110 RGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERS 174

  Fly   158 NREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAV----AKLAV 218
            ...:|....|:|:..:||.:|||:|:.......|:..|...:.|.:..|.|.::||    ||:..
Human   175 GHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLE 239

  Fly   219 DAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSADGIKRICLELGGNAP 283
            |..:|..:.::  |...|.||....|...|..:||||||:|||.:.....:...|..||||||..
Human   240 DNKLPGAICSL--TCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNA 302

  Fly   284 FIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQGCDV 348
            .|.|:.||:...|..|:.:.....||.|.:|.|.|:.:|::|:.|.:|||....:::|:....:|
Human   303 IIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNV 367

  Fly   349 QIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVFGP 413
            ..|||..:...:...|.||:|:.:...::.||:.: |:...:..|||||.:...|.:...|.|.|
Human   368 LYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVM-DRPGNYVEPTIVTGLGHDASIAHTETFAP 431

  Fly   414 VVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFR--VAKRLEVGMVGVNEGIISAAE--AP 474
            ::.:.:|::|||.....|:.::||:...::::|.::||  ..|..:.|:|.||.. .|.||  ..
Human   432 ILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIP-TSGAEIGGA 495

  Fly   475 FGGVKESGVGREGSKHGIDDYV 496
            |||.|.:|.|||........|:
Human   496 FGGEKHTGGGRESGSDAWKQYM 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	136/456 (30%)
ALDH7A1	NP_001173.2	ALDH_F7_AASADH	53..527	CDD:143448	139/474 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810