DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and aldh1l1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001011027.1	Gene:	aldh1l1 / 496436	XenbaseID:	XB-GENE-1016237	Length:	902	Species:	Xenopus tropicalis

Alignment Length:	482	Identity:	172/482 - (35%)
Similarity:	287/482 - (59%)	Gaps:	10/482 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VQDKALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTAK 91
            :..:..::|.::|:...| |::..||.:|..|.||....|:|..:|:.|||:|:|:.||..:..:
Frog   420 IPHQLFINGQFIDAEGGK-TYDTVNPTDGTAICKVSLAQVSDIDRAVAAAKEAFENGEWGKMNPR 483

  Fly    92 DRSNLLKKWHKLIEQHSQEIAEIMTAESGKPINES-KGEVAYGNAFVEWFAEEARRIYGEIVP-- 153
            ||..:|.:...::|:|.:|:|.|.:.:||.....: |..|........:||....:|.|..:|
Frog   484 DRGRILYRLADIMEEHQEELATIESIDSGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPIN 548

  Fly   154 SASPNREI-IVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLA 217
            .|.|||.: ...::||||..::.|||:|:.|:..|..|.||||.|||:||::.||||||..|:|:
Frog   549 QARPNRNLTFTRREPIGVCGIVIPWNYPLMMLAWKTAACLAAGNTVVLKPAQVTPLTALKFAELS 613

  Fly   218 VDAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSADG-IKRICLELGGN 281
            |.|||||||||:: ....:.||......||||.|.|||||.:||.:.::.|.| :|::.|||||.
Frog   614 VKAGIPKGVINIL-PGAGSLIGQRLSDHPDVRKIGFTGSTPIGKHIMKSCAVGNVKKVSLELGGK 677

  Fly   282 APFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQGC 346
            :|.|:|...|::|||...|:|.|.|.|:.|::|.|.|:::|::|:||.::...|:.:||||....
Frog   678 SPLIIFQDCDLDKAVRMGMSSVFFNKGENCIAAGRLFLEESIHDEFVKRVVGEVKKMKIGDPLDR 742

  Fly   347 DVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVF 411
            ....||..::...:|:..:.:....:.|.::.||:.: ::...|:.|||.|||.....:..||.|
Frog   743 STDHGPQNHKAHLDKLIEYCQTGVKEGAKLVYGGKQV-ERPGFFFEPTIFTDVTDEMFIAKEESF 806

  Fly   412 GPVVSIIRFR--DEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAP 474
            ||::.|.:|:  |.:|.:|:||:|..|||...:::::.:...|:::|:.|.|.||....:...||
Frog   807 GPIMIISKFKDGDVDEVLKRANNTEFGLASGVFTKDISKALYVSEKLQAGTVFVNTYNKTDVAAP 871

  Fly   475 FGGVKESGVGREGSKHGIDDYVDIKYI 501
            |||.|:||.|::..:..:::|:..|.:
Frog   872 FGGFKQSGFGKDLGEEALNEYLKTKAV 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	168/460 (37%)
aldh1l1	NP_001011027.1	FMT_core_FDH_N	1..203	CDD:187716
		GART	1..203
		FDH_Hydrolase_C	206..305	CDD:187731
		PP-binding	325..391	CDD:376348
		ALDH_F1L_FTFDH	417..902	CDD:143458	172/482 (36%)
		Aldehyde dehydrogenase	417..902		172/482 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910