DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ssadh and aldh16a1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001073423.2	Gene:	aldh16a1 / 492710	ZFINID:	ZDB-GENE-070112-2062	Length:	795	Species:	Danio rerio

Alignment Length:	483	Identity:	121/483 - (25%)
Similarity:	220/483 - (45%)	Gaps:	63/483 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AWVDSSNAKATF----EVRNPAN----------GAVIGKVPNMTVADAQKAIDAAKQAYESKEWR 86
            :|::..:....|    :..:||:          .||:.........|...|:.:|...:  |.|.
Zfish    30 SWLEKHSRTLGFFIDGKFSHPADRQTQDVIDSKAAVVCSTVCAQAEDVASAVSSAAAGF--KTWS 92

  Fly    87 SLTAKDRSNLLKKWHKLIEQHSQEIAEIMTAESGKPINESKGEVAYGNAFVEWFAEEARRIYGEI 151
            .|:...|:.:|.|...::::|||.::|:.      .:::|....|......:::|..| ::....
Zfish    93 QLSCYQRAKVLLKLPGVLQRHSQCVSEVC------ELSQSTTSPAVLIRLAQYYASWA-QLRDTR 150

  Fly   152 VPSASPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKL 216
            :|..||.          ||..::...:..:..:..|...|||.|..|:|.|.:.|.|..|.:|:|
Zfish   151 MPEWSPQ----------GVVTVVVSDDCSVYFLLLKVLPALAMGNAVIVVPGKTTALPGLLLAQL 205

  Fly   217 AVDAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSADGIKRICLELGGN 281
            .::||:|.||:||:|.::|: :.....::|.|..::|:|..:.|:.:.:.:|.....:...|..:
Zfish   206 FMEAGMPAGVLNVLTGSEAS-LAAKMAQNPQVNYLTFSGCRQTGEAVAKAAAGWGVPMTFSLSSS 269

  Fly   282 A--PFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFF-----VQDSVYDKFVGQLKKRVEALK 339
            :  |||:|:|||::.||||.:...|:.        .|.|     ||:||.|..|.:||.|:..:|
Zfish   270 SVCPFIIFESADLDSAVDGVIELAFKK--------KRDFQWVLCVQESVLDSVVARLKTRMAEMK 326

  Fly   340 IGDGQGCDVQIG-PLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSA 403
                       | ||.::...:.:...:::|:.:.|.:|....|....|  .|.||::..:.||.
Zfish   327 -----------GVPLASDPDRSIIDAAIQEAQQQGATLIQSCPPASTGG--LYPPTVLCGLAPSC 378

  Fly   404 QLYSEEVFGPVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGII 468
            :.......|||:.:|.||...|.|...|.:..|.|...::|:|......||.|.||.|.||...:
Zfish   379 ESVISPPPGPVLPLITFRSSAEGVTLGNHSPHGQAASIWTEDLTLALESAKSLCVGSVWVNCHSV 443

  Fly   469 SAAEAPFGGVKESGVGREGSKHGIDDYV 496
            .....|..|.::||...:|.:.|:..::
Zfish   444 MDPALPLCGRRDSGNCTDGGREGLYQFL 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	119/466 (26%)
aldh16a1	NP_001073423.2	ALDH-SF	18..470	CDD:299846	121/480 (25%)
aldh16a1	NP_001073423.2	AdhE	514..>755	CDD:223944
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810