DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ssadh and P5CDh1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	153/592 - (25%)
Similarity:	253/592 - (42%)	Gaps:	109/592 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWRQLSGVARTGSSL--SLCR--MRGFSALVQDKALVD---------GAWVDSSNAKATFE-VRN 51
            |.|.:...:...|||  ||.:  .|...:::.|..|.|         |...||...||..: ::.
  Fly     1 MLRMMRSSSSRCSSLQQSLLKSSTRCLGSVIPDLKLKDFPIANEPILGYLKDSKERKALEQALKG 65

  Fly    52 PANGA-----VIG--------------------KVPNMTVADAQKAIDAAKQAYESK-EWRSLTA 90
            .|:..     |||                    |:.:...||.:....|.|.|.|:: :|..::.
  Fly    66 TASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVETQPKWDRVSI 130

  Fly    91 KDRSNLLKKWHK----LIEQHSQEI-AEIMTAESGKPINESKGEVAYGNAFVE---WFAEEARRI 147
            .||   ||.|.|    :...:.|:: |..|..:|...|.......|....|:.   :|.:|..:
  Fly   131 ADR---LKIWEKAADLMATTYRQDLNAATMLGQSKTAIQAEIDSAAELIDFIRMNAYFLKEVTK- 191

  Fly   148 YGEIVPSASPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALA-----AGCTVVVKPSEDTP 207
            |..|..:....:..:..:...|..|.::|:||      ...|..|:     .|..|:.|||:...
  Fly   192 YQPISENIKVTKNSLRYRGIDGFIAAVSPFNF------TAIGGNLSYTPALMGNGVLWKPSDTAM 250

  Fly   208 LTALAVAKLAVDAGIPKGVINVVTTNKAAPI-GDLFCKSPDVRGISFTGSTEVGKLLFRNSADGI 271
            |:...:.|:..:||:|.||:|.|..:  .|: ||....||.:.||:||||......|::...:.|
  Fly   251 LSNWIIFKIMREAGVPDGVVNFVPAD--GPVFGDTITASPHLAGINFTGSVPTFNRLWKQVGNNI 313

  Fly   272 ------KRICLELGGNAPFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQ 330
                  .|:..|.||.....:..|||:|..|...:.|.|..|||.|.:.:|.:|.:|::.:....
  Fly   314 DNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVPESLWPQIKEG 378

  Fly   331 LKKRVEALKIGDGQGCDVQIGPLINEMQFNKVSGFVEDARSKKANI-ILGGQPLPDKGSLFYAPT 394
            |......|||||.|........:|::..|.:::|::|.|: |..|: ||.|....|....|..||
  Fly   379 LVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAK-KSPNLEILAGGTYSDSKGYFVNPT 442

  Fly   395 IVTDVPPSAQLYSEEVFGPVVSIIRFRDEE--EAVKKAN-DTRRGLAGYFYSEN-------LQQV 449
            ||....|..::.:||:||||:||..:::.:  |.:|..: .|:..|.|..:.::       ||:
  Fly   443 IVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFALTGAVFGQDEDFVKCALQE- 506

  Fly   450 FRVAKRLEVGMVGVNE---GIISAAEAPFGGVKESGVG-REGSKHGI----------DDYVDIK- 499
            |::|    .|...:|:   |.: ..:.||||.:.||.. :.|..|.|          :.:|.::
  Fly   507 FKMA----AGNFYINDKSTGSV-VGQQPFGGGRMSGTNDKAGGPHYILRWTSPQSIKETFVPLRD 566

  Fly   500 ----YIC 502
                |:|
  Fly   567 VNYPYMC 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	137/530 (26%)
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	139/540 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454115
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740