DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and Aldh7A1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	481	Identity:	131/481 - (27%)
Similarity:	231/481 - (48%)	Gaps:	40/481 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTAKDRSNLLKK 99
            |.|.....:..:::   |..|..|.||....|.:.:..|..|.:||  |:||.:.|..|..::::
  Fly    55 GQWQGRGPSVTSYD---PGTGQPIAKVRQGNVQELEHTIGLAVEAY--KQWRQVPAPVRGEIVRQ 114

  Fly   100 WHKLIEQHSQEIAEIMTAESGKPINESKGEVAYGNAFVEW--FAEEARRIY-GEIVPSASPNREI 161
            ....:.::.:.:.::::.|.||..:|.:|||   ..|::.  :|....||| |:::.|...:..|
  Fly   115 IGDELRKYKEPLGKLVSLEVGKIYSEGQGEV---QEFIDICDYAVGLSRIYSGQLINSERADHSI 176

  Fly   162 IVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLAVDAGIPKGV 226
            :...:|:||..:|:.:|||.|:....|..||..|.:|:.|.:..|||.::|..|:         |
  Fly   177 LEAWRPLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKI---------V 232

  Fly   227 INVVTTNKAAP----------IGDLFCKSPDVRGISFTGSTEVGKLLFRNSADGIKRICLELGGN 281
            ..|:..|...|          :|........|..:|||||.:.|:.:.........::.||||||
  Fly   233 AEVLRRNNLPPVVTLCQGGTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGKVILELGGN 297

  Fly   282 APFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEAL--KIGDGQ 344
            ...|:.:||:::.|:|.|:.......||.|.:..|..|.:.::|:||.:|..:.:.|  |||...
  Fly   298 NALIIDESANVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQL 362

  Fly   345 GCDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYA-PTIVTDVPPSAQLYSE 408
            .....:||:..:.........:.:|:|....:..||..:...|  ||. ||::|.:|..|.:...
  Fly   363 EAQTLVGPVHTQQNVENYKAAIAEAKSLGGTVAFGGNVIQRDG--FYVEPTVITGLPHDASVVHR 425

  Fly   409 EVFGPVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFR--VAKRLEVGMVGVNEGIISAA 471
            |.|.|:|.|::.::.::|::..|:..:||:...::||:.|.|:  .||..:.|:|.:|. ..:.|
  Fly   426 ETFAPIVYILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINT-TTNGA 489

  Fly   472 E--APFGGVKESGVGREGSKHGIDDY 495
            |  ..|||.|.:|.|||........|
  Fly   490 EIGGAFGGEKATGGGRESGSDAWKQY 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	129/467 (28%)
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	131/481 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454097
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740