DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and Aldh16a1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001028878.1	Gene:	Aldh16a1 / 361571	RGDID:	1566295	Length:	802	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	142/497 - (28%)
Similarity:	234/497 - (47%)	Gaps:	56/497 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VDGAWVDSSNAKATFEVRNPA------NGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTAK 91
            |:|.|:..       |.||||      .|..:.........|...|::||:..:  |.|..|...
  Rat    44 VNGMWLKP-------EHRNPAPCQDPITGENLASCLQAEAEDISAAVEAARITF--KTWSQLPGT 99

  Fly    92 DRSNLLKKWHKLIEQHSQEIAEIMTAESGKPINESK-GEVAYGNAFVEWFAEEARRIYGEIVPSA 155
            .|...|.:..|:|::|.:.:..:.:..:|:.:.|.: |::......:.:.|.:|     ....||
  Rat   100 ARGQHLTRLAKVIQKHQRLLWTLESLVTGRAVREVRDGDIPLAQQLLHYHALQA-----HAQDSA 159

  Fly   156 SPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVV--VKPSEDTPLTALAVAKLAV 218
            ..:.|      |:||..||.|.:|....:..:...|||.|||||  |.||..||   |.:|:||.
  Rat   160 LADWE------PLGVIGLILPTSFSFLDMMWRVCPALAMGCTVVALVPPSFPTP---LLLAQLAG 215

  Fly   219 DAGIPKGVINVVTTNKAAPI--GDLFCKSPDVRGISFTGSTEVGKLLFRNSADGIKRICLELGGN 281
            :.|...|::|||    ..|:  |.:....|.|:.::|.|:.|.|:.|.:..|.....:.|.||..
  Rat   216 ELGSFPGILNVV----CGPVSLGPVLASQPGVQKVAFCGAVEEGRALRQTLAGRGATLGLALGTE 276

  Fly   282 APFIVFDSADIEKAVDGAMASKF--RNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQ 344
            :..::.||||::.||:|.:.:.:  |:.|     ..|..:|:||:|:.:.:|:.|:..::.|.|.
  Rat   277 SLLLLTDSADVDSAVEGVVDAVWSDRSLG-----GLRLLIQESVWDEAMKRLQARMAQIRSGKGL 336

  Fly   345 GCDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEE 409
            ...|.:|.. .....:....||::|:|:...:...|. :| ..|.|::||:|:.:||:|.....|
  Rat   337 DGAVDMGAR-GAAARDLAQSFVDEAQSQGGQVFQAGD-MP-SNSPFFSPTLVSGLPPAAPCAQAE 398

  Fly   410 VFGPVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAP 474
            |..|||....||..:||:..||.|.||.:...:||.|.|...:...|:||.|.:|...:.....|
  Rat   399 VPWPVVMASPFRTVKEALALANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPAVP 463

  Fly   475 FGGVKESGVGREGSKHGIDDYVDI-------KYICMGNLKYD 509
            .||.||||....|...|:.:|:.:       .::| .:|.||
  Rat   464 TGGCKESGSSWHGGPDGLYEYLQLLGTPYRESFLC-ESLNYD 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	134/473 (28%)
Aldh16a1	NP_001028878.1	ALDH-SF	19..491	CDD:416387	138/481 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..554
		ALDH-SF	550..>765	CDD:416387
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810