DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and CG8665

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_610107.1	Gene:	CG8665 / 35407	FlyBaseID:	FBgn0032945	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	482	Identity:	167/482 - (34%)
Similarity:	267/482 - (55%)	Gaps:	10/482 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VQDKALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTAK 91
            |..:..::|.:|| :.|:.|.|:.||.|..|:.||...:..|..||:.||..|:.. .||.:|.:
  Fly   431 VPTQLFINGEFVD-AEAQRTLEIVNPTNEEVLCKVACASATDVDKAVRAAHSAFYG-SWRQITPR 493

  Fly    92 DRSNLLKKWHKLIEQHSQEIAEIMTAESGKPINES-KGEVAYGNAFVEWFAEEARRIYGEIVP-- 153
            .|..|:.....|:|::.:|:|.|.:.:||.....: |..|........:||....:|.|..:|
  Fly   494 QRGQLMLNLADLMERNKEELATIESVDSGAVYTLALKTHVGMSIEAWRYFAGWCDKIQGNTIPVN 558

  Fly   154 SASPNREI-IVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLA 217
            .|.||..: ...|:||||..||||||:|:.|::.|..|.:|||.|.::||::..|||||..|:|.
  Fly   559 PARPNNVLTFTRKEPIGVCGLITPWNYPLMMLSWKMAACIAAGNTCLIKPAQTCPLTALKFAELT 623

  Fly   218 VDAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSAD-GIKRICLELGGN 281
            |.||.|.|||||: ..|.:..|........||.:.|||||.:||.:.::.|| .:|:..|||||.
  Fly   624 VRAGFPPGVINVL-PGKGSDAGQAVADHELVRKLGFTGSTPIGKHIMKSCADSNLKKCSLELGGK 687

  Fly   282 APFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQGC 346
            :|.|:|...|::|||...|:|.|.|.|:.|::|.|.||:|.::|:|:.::.|.:..:.|||....
  Fly   688 SPLIIFADCDMDKAVKHGMSSVFFNKGENCIAAGRLFVEDRIHDEFIRRVLKDLRTMTIGDPLDR 752

  Fly   347 DVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVF 411
            ....||..::..|:|:..|......:.|.::.||..:|:....|:.||:.|:|.....:..||.|
  Fly   753 STAHGPQNHKAHFDKLLEFCRRGVDEGAKLVYGGCRVPNLKGYFFTPTVFTNVTDDMFIAQEESF 817

  Fly   412 GPVVSIIRFR--DEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAP 474
            ||::.|.:|.  |.:..:::||.|..|||...:::::.:....|.|:|.|.|.||....:...||
  Fly   818 GPIMIISKFNGSDIDSLMQRANRTEYGLASGVFTKDIGKALNFADRIEAGTVFVNVYNKTDVAAP 882

  Fly   475 FGGVKESGVGREGSKHGIDDYVDIKYI 501
            |||.|:||.|::..:..:::|:..|.:
  Fly   883 FGGFKQSGYGKDLGQEALNEYLKTKCV 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	160/460 (35%)
CG8665	NP_610107.1	Fmt	4..315	CDD:223301
		FMT_core	5..207	CDD:294280
		FDH_Hydrolase_C	212..316	CDD:187731
		PP-binding	338..403	CDD:278949
		PLN02466	396..909	CDD:215259	167/480 (35%)
		ALDH_F1L_FTFDH	428..913	CDD:143458	167/482 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454124
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740