DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ssadh and Aldh1b1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001011975.1	Gene:	Aldh1b1 / 298079	RGDID:	1306737	Length:	519	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	167/479 - (34%)
Similarity:	264/479 - (55%)	Gaps:	13/479 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DKALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYE-SKEWRSLTAKD 92
            ::..::..|.|:. :|.||...||..|.|||.|.....||...|:.||::|:. ...||.:.|.:
  Rat    39 NQLFINNEWHDAV-SKKTFPTVNPTTGEVIGHVAEGDRADVDLAVRAAREAFRLGSPWRRMDASE 102

  Fly    93 RSNLLKKWHKLIEQHSQEIAEIMTAESGKPINES----KGEVAYGNAFVEWFAEEARRIYGEIVP 153
            |..||.:...|:|:....:|.:.|.::|||..||    ..||.   ....:.|..|.:.:|:.:|
  Rat   103 RGRLLNRLADLVERDRVYLASLETLDNGKPFQESYVLDLDEVI---KVYRYLAGWADKWHGKTIP 164

  Fly   154 SASPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLAV 218
             ...........:|:||...|.|||||:.|...|...|||.|.|||:|.:|.|||:||.:|.|..
  Rat   165 -MDGEHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIK 228

  Fly   219 DAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSAD-GIKRICLELGGNA 282
            :||.|.||:|:: |......|....:..||..::||||||||.|:.:.:.| .:||:.|||||.:
  Rat   229 EAGFPPGVVNII-TGYGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKS 292

  Fly   283 PFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQGCD 347
            |.||...||::.|||....:.|.|.||.|.:.:|.||::|:|.:|:.:..::.:..|:|:....|
  Rat   293 PSIVLADADMDHAVDQCHEALFFNMGQCCCAGSRTFVEESIYHEFLERTVEKAKKRKVGNPFELD 357

  Fly   348 VQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVFG 412
            .|.||.:::.||.|:.|::...:.:.|.::.||:...::| .|..||:..:|....::..||:||
  Rat   358 TQQGPQVDKEQFEKILGYIRLGQKEGAKLLCGGERFGERG-FFIKPTVFGNVQDDMRIAREEIFG 421

  Fly   413 PVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAPFGG 477
            ||..:.:|:..||.:::||:||.|||...::.:|.:....::.|:.|.|.||...|.....||||
  Rat   422 PVQPLFKFKKIEEVIQRANNTRYGLAAAVFTRDLDKALYFSQALQAGTVWVNTYNIVTCHTPFGG 486

  Fly   478 VKESGVGREGSKHGIDDYVDIKYI 501
            .||||.|||..:.|:..|.::|.:
  Rat   487 FKESGNGRELGEDGLKAYTEVKTV 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	162/459 (35%)
Aldh1b1	NP_001011975.1	PLN02466	13..510	CDD:215259	167/477 (35%)
Aldh1b1	NP_001011975.1	ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	167/479 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810