DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and Aldh2

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_115792.2	Gene:	Aldh2 / 29539	RGDID:	69219	Length:	519	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	177/527 - (33%)
Similarity:	278/527 - (52%)	Gaps:	43/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWRQLSGVARTGSSLSLCRMRGFSALVQ----------DKALVDGAWVDSSNAKATFEVRNPANG 55
            |.|.....||.|..||.......::.|.          ::..::..|.|:. :|.||...||:.|
  Rat     1 MLRAALSTARRGPRLSRLLSAAATSAVPAPNQQPEVFCNQIFINNEWHDAV-SKKTFPTVNPSTG 64

  Fly    56 AVIGKVPNMTVADAQKAIDAAKQAYE-SKEWRSLTAKDRSNLLKKWHKLIEQHSQEIAEIMTAES 119
            .||.:|......|..||:.||:.|:: ...||.:.|.||..||.:...|||:....:|.:.|.::
  Rat    65 EVICQVAEGNKEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDN 129

  Fly   120 GKPINESKGEVAYGNAF----------VEWFAEEARRIYGEIVP----SASPNREIIVMKQPIGV 170
            |||         |..::          :.::|..|.:.:|:.:|    ..|..|.     :|:||
  Rat   130 GKP---------YVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRH-----EPVGV 180

  Fly   171 AALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLAVDAGIPKGVINVVTTNKA 235
            ...|.|||||:.|...|.|.|||.|..||:|.:|.||||||.||.|..:||.|.||:|:| ....
  Rat   181 CGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIV-PGFG 244

  Fly   236 APIGDLFCKSPDVRGISFTGSTEVGKLL-FRNSADGIKRICLELGGNAPFIVFDSADIEKAVDGA 299
            ...|.......||..::||||||||.|: ....:..:||:.|||||.:|.|:...||::.||:.|
  Rat   245 PTAGAAIASHEDVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQA 309

  Fly   300 MASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQGCDVQIGPLINEMQFNKVSG 364
            ..:.|.|.||.|.:.:|.|||:.|||:||.:...|.::..:|:......:.||.::|.||.|:.|
  Rat   310 HFALFFNQGQCCCAGSRTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILG 374

  Fly   365 FVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVFGPVVSIIRFRDEEEAVKK 429
            :::..:.:.|.::.||....|:| .|..||:..||.....:..||:||||:.|::|:..||.|.:
  Rat   375 YIKSGQQEGAKLLCGGGAAADRG-YFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGR 438

  Fly   430 ANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAPFGGVKESGVGREGSKHGIDD 494
            ||:::.|||...::::|.:...:::.|:.|.|.:|...:..|::||||.|.||.|||..::|:..
  Rat   439 ANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQA 503

  Fly   495 YVDIKYI 501
            |.::|.:
  Rat   504 YTEVKTV 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	164/469 (35%)
Aldh2	NP_115792.2	ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	169/495 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810