Protein Alignment Ssadh and ALDH1A3

DIOPT Version :9

• Sequence 1: NP_001014665.1
• Gene: Ssadh / 43092
• FlyBaseID: FBgn0039349
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000684.2
• Gene: ALDH1A3 / 220
• HGNCID: 409
• Length: 512
• Species: Homo sapiens
• Alignment Length: 487
• Identity: 176/487 - (36%)
• Similarity: 266/487 - (54%)
• Gaps: 31/487 - (6%)

  Fly    30 KALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYE-SKEWRSLTAKDR 93
            |..::..|.:|.:.| .|...||:....|.:|......|..||::||:.|:: ...||.|.|..|
Human    33 KIFINNEWHESKSGK-KFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSR 96

  Fly    94 SNLLKKWHKLIEQHSQEIAEIMTAESGKPINESKGEVAYGNAF----------VEWFAEEARRIY 148
            ..||.:...|:|:....:|.:.|.::|||         :.:||          :.:||..|.:|.
Human    97 GRLLHQLADLVERDRATLAALETMDTGKP---------FLHAFFIDLEGCIRTLRYFAGWADKIQ 152

  Fly   149 GEIVPSASPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAV 213
            |:.:|: ..|.......:||||...|||||||:.|:..|...||..|.|:|:||:|.||||||.:
Human   153 GKTIPT-DDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYL 216

  Fly   214 AKLAVDAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFR-NSADGIKRICLE 277
            ..|..:||.|.||:|:| ......:|......|.:..|:||||||||||:.. .|...:||:.||
Human   217 GSLIKEAGFPPGVVNIV-PGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLE 280

  Fly   278 LGGNAPFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALK--- 339
            |||..|.||...||::.||:.|....|.|.||.|.:|:|.||::.||.:||   ::.||..|
Human   281 LGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFV---RRSVEYAKKRP 342

  Fly   340 IGDGQGCDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQ 404
            :||......:.||.|::.||:|:...:|..:.:.|.:..||..:.||| ||..||:.::|..:.:
Human   343 VGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKG-LFIKPTVFSEVTDNMR 406

  Fly   405 LYSEEVFGPVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIIS 469
            :..||:||||..|::|:..||.:|:||.|..||....:::||.:..::|..||.|.|.:|.....
Human   407 IAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNAL 471

  Fly   470 AAEAPFGGVKESGVGREGSKHGIDDYVDIKYI 501
            .|:|||||.|.||.|||..::.:.:|.::|.:
Human   472 YAQAPFGGFKMSGNGRELGEYALAEYTEVKTV 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	171/468 (37%)
ALDH1A3	NP_000684.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22
		ALDH_F1AB_F2_RALDH1	26..506	CDD:143459	176/487 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810