DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and ALDH1B1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_000683.3	Gene:	ALDH1B1 / 219	HGNCID:	407	Length:	517	Species:	Homo sapiens

Alignment Length:	479	Identity:	169/479 - (35%)
Similarity:	266/479 - (55%)	Gaps:	13/479 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DKALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYE-SKEWRSLTAKD 92
            ::..::..|.|:. :|.||...||..|.|||.|.....||..:|:.||::|:. ...||.:.|.:
Human    37 NQLFINNEWQDAV-SKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASE 100

  Fly    93 RSNLLKKWHKLIEQHSQEIAEIMTAESGKPINESKG----EVAYGNAFVEWFAEEARRIYGEIVP 153
            |..||.:...|:|:....:|.:.|.::|||..||..    ||.   ....:||..|.:.:|:.:|
Human   101 RGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVI---KVYRYFAGWADKWHGKTIP 162

  Fly   154 SASPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLAV 218
             ...........:|:||...|.|||||:.|...|...|||.|.|||:|.:|.|||:||.:|.|..
Human   163 -MDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIK 226

  Fly   219 DAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSAD-GIKRICLELGGNA 282
            :||.|.||:|:: |......|....:..||..::||||||||.|:.:.:.| .:||:.|||||.:
Human   227 EAGFPPGVVNII-TGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKS 290

  Fly   283 PFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQGCD 347
            |.||...||:|.||:....:.|.|.||.|.:.:|.||::|:|::|:.:..::.:..|:|:....|
Human   291 PSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELD 355

  Fly   348 VQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVFG 412
            .|.||.:::.||.:|.|:::..:.:.|.::.||:...::| .|..||:...|....::..||:||
Human   356 TQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERG-FFIKPTVFGGVQDDMRIAKEEIFG 419

  Fly   413 PVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAPFGG 477
            ||..:.:|:..||.|::||:||.|||...::.:|.:.....:.|:.|.|.||...|.....||||
Human   420 PVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGG 484

  Fly   478 VKESGVGREGSKHGIDDYVDIKYI 501
            .||||.|||..:.|:..|.::|.:
Human   485 FKESGNGRELGEDGLKAYTEVKTV 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	164/459 (36%)
ALDH1B1	NP_000683.3	ALDH_F1AB_F2_RALDH1	31..511	CDD:143459	169/479 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810