DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ssadh and ALDH2

DIOPT Version :10

Sequence 1:NP_651408.1 Gene:Ssadh / 43092 FlyBaseID:FBgn0039349 Length:509 Species:Drosophila melanogaster
Sequence 2:NP_000681.2 Gene:ALDH2 / 217 HGNCID:404 Length:517 Species:Homo sapiens


Alignment Length:489 Identity:166/489 - (33%)
Similarity:266/489 - (54%) Gaps:33/489 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 DKALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYE-SKEWRSLTAKD 92
            ::..::..|.|:.:.| ||...||:.|.||.:|......|..||:.||:.|:: ...||.:.|..
Human    37 NQIFINNEWHDAVSRK-TFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASH 100

  Fly    93 RSNLLKKWHKLIEQHSQEIAEIMTAESGKPINESKGEVAYGNAF----------VEWFAEEARRI 147
            |..||.:...|||:....:|.:.|.::|||         |..::          :.::|..|.:.
Human   101 RGRLLNRLADLIERDRTYLAALETLDNGKP---------YVISYLVDLDMVLKCLRYYAGWADKY 156

  Fly   148 YGEIVP----SASPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPL 208
            :|:.:|    ..|..|.     :|:||...|.|||||:.|...|.|.|||.|..||:|.:|.|||
Human   157 HGKTIPIDGDFFSYTRH-----EPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPL 216

  Fly   209 TALAVAKLAVDAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLL-FRNSADGIK 272
            |||.||.|..:||.|.||:|:| .......|.......||..::||||||:|::: ....:..:|
Human   217 TALYVANLIKEAGFPPGVVNIV-PGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLK 280

  Fly   273 RICLELGGNAPFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEA 337
            |:.|||||.:|.|:...||::.||:.|..:.|.|.||.|.:.:|.|||:.:||:||.:...|.::
Human   281 RVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKS 345

  Fly   338 LKIGDGQGCDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPS 402
            ..:|:......:.||.::|.||.|:.|::...:.:.|.::.||....|:| .|..||:..||...
Human   346 RVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRG-YFIQPTVFGDVQDG 409

  Fly   403 AQLYSEEVFGPVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGI 467
            ..:..||:||||:.|::|:..||.|.:||::..|||...::::|.:...:::.|:.|.|.||...
Human   410 MTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYD 474

  Fly   468 ISAAEAPFGGVKESGVGREGSKHGIDDYVDIKYI 501
            :..|::||||.|.||.|||..::|:..|.::|.:
Human   475 VFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTV 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SsadhNP_651408.1 ALDH_F5_SSADH_GabD 49..503 CDD:143421 161/469 (34%)
ALDH2NP_000681.2 SIFI-degron. /evidence=ECO:0000269|PubMed:38297121 9..24
ALDH_F1AB_F2_RALDH1 31..511 CDD:143459 166/489 (34%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.