DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and Aldh1l2

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_705771.2	Gene:	Aldh1l2 / 216188	MGIID:	2444680	Length:	923	Species:	Mus musculus

Alignment Length:	491	Identity:	166/491 - (33%)
Similarity:	281/491 - (57%)	Gaps:	10/491 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 MRGFSALVQDKALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKE 84
            :.|.:..:..:..::|.:||:.:.: |:...||.:|..|.:|...::||..:|:.|||.|:|:.|
Mouse   434 VNGMTVKIPYQCFINGQFVDAEDGE-TYATVNPTDGTTICRVSYASLADVDRAVAAAKDAFENGE 497

  Fly    85 WRSLTAKDRSNLLKKWHKLIEQHSQEIAEIMTAESGKPINES-KGEVAYGNAFVEWFAEEARRIY 148
            |..:.|:||..|:.:...|:|::.:|:|.|...:||.....: |..:........:||....:|.
Mouse   498 WGRMNARDRGRLMYRLADLMEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQ 562

  Fly   149 GEIVP--SASPNREI-IVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTA 210
            |..:|  .|.||..: ...|:|:|..|:|.|||:|:.|:..|:.|.||||.|:|:||::.|||||
Mouse   563 GSTIPINQARPNYNLTFTKKEPLGACAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTA 627

  Fly   211 LAVAKLAVDAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSA-DGIKRI 274
            |..|:|.|.||.||||||:: .......|....:.||:|.:.|||||.|||.:.::.| ..:|::
Mouse   628 LKFAELTVKAGFPKGVINII-PGSGGVAGQRLSQHPDIRKLGFTGSTSVGKQIMKSCAVSNLKKV 691

  Fly   275 CLELGGNAPFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALK 339
            .|||||.:|.|:|...|:||||...|.:.|.|.|:.|::|.|.||:::::|:||.::.:.::.:|
Mouse   692 SLELGGKSPLIIFSDCDLEKAVRMGMGAVFFNKGENCIAAGRLFVEEAIHDEFVTRVVEEIKKMK 756

  Fly   340 IGDGQGCDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQ 404
            |||........||..:.....|:..:.|....:.|.::.||:.:...| .|..||:.|.|.....
Mouse   757 IGDPLDRSTDHGPQNHRAHLEKLLQYCETGVQEGATLVYGGRQVQRPG-FFMEPTVFTGVEDHMY 820

  Fly   405 LYSEEVFGPVVSIIRFR--DEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGI 467
            |..||.|||::.|.:|:  |.:..:::||:|..|||...::.::.:...|:.:||.|.|.:|...
Mouse   821 LAKEESFGPIMVISKFQNGDIDGVLQRANNTEYGLASGVFTRDINKAMYVSDKLEAGTVFINTYN 885

  Fly   468 ISAAEAPFGGVKESGVGREGSKHGIDDYVDIKYICM 503
            .:...|||||:|:||.|::..:..:::|:.||.:.:
Mouse   886 KTDVAAPFGGMKQSGFGKDLGEEALNEYLKIKTVTL 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	161/460 (35%)
Aldh1l2	NP_705771.2	Fmt	22..326	CDD:223301
		FMT_core_FDH_N	23..225	CDD:187716
		GART	23..225
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..410	CDD:278949
		ALDH_F1L_FTFDH	438..923	CDD:143458	165/487 (34%)
		Aldehyde dehydrogenase	438..923		165/487 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810