DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and Aldh5a1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_766120.1	Gene:	Aldh5a1 / 214579	MGIID:	2441982	Length:	523	Species:	Mus musculus

Alignment Length:	484	Identity:	254/484 - (52%)
Similarity:	355/484 - (73%)	Gaps:	9/484 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LVQDKALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTA 90
            |::..:.|.|.|:.   |.|||.|.:||:||.:|.|.:..|.:|:.|:.||..|:.|  |:.::.
Mouse    46 LLRGDSFVGGRWLP---APATFPVYDPASGAKLGTVADCGVPEARAAVRAAYDAFNS--WKGVSV 105

  Fly    91 KDRSNLLKKWHKLIEQHSQEIAEIMTAESGKPINESKGEVAYGNAFVEWFAEEARRIYGEIVPSA 155
            |:||.||:||:.|:.|:..::|:|:|||||||:.|::||:.|...|:|||:||||||||:|:.::
Mouse   106 KERSLLLRKWYDLMIQNKDDLAKIITAESGKPLKEAQGEILYSALFLEWFSEEARRIYGDIIYTS 170

  Fly   156 SPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLAVDA 220
            :.::..:|:|||:||||:|||||||.||||||.||||||||||||||:||||.:|||:|:||..|
Mouse   171 AKDKRGLVLKQPVGVAAIITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPYSALALAQLANQA 235

  Fly   221 GIPKGVINVV--TTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSADGIKRICLELGGNAP 283
            |||.||.||:  :.|||..:|::.|..|.|..|||||||..||:|..::|:.:||:.:||||.||
Mouse   236 GIPAGVYNVIPCSRNKAKEVGEVLCTDPLVSKISFTGSTATGKILLHHAANSVKRVSMELGGLAP 300

  Fly   284 FIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRV-EALKIGDGQGCD 347
            |||||||::::||.|||||||||.|||||.:|||.||..::|.||.:..:.: ::|::|:|....
Mouse   301 FIVFDSANVDQAVAGAMASKFRNAGQTCVCSNRFLVQRGIHDSFVTKFAEAMKKSLRVGNGFEEG 365

  Fly   348 VQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVFG 412
            ...||||||....||...|.||.:|.|.::.||: ....|..|:.||::::|.......:||.||
Mouse   366 TTQGPLINEKAVEKVEKQVNDAVAKGATVVTGGK-RHQSGGNFFEPTLLSNVTRDMLCITEETFG 429

  Fly   413 PVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAPFGG 477
            |:..:|:|..|||||..||....||||||||::..|::|||::|||||||||||:||:.|.||||
Mouse   430 PLAPVIKFDKEEEAVAIANAAEVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGG 494

  Fly   478 VKESGVGREGSKHGIDDYVDIKYICMGNL 506
            ||:||:||||||:|||:|:::||:|.|.|
Mouse   495 VKQSGLGREGSKYGIDEYLEVKYVCYGGL 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	243/456 (53%)
Aldh5a1	NP_766120.1	SSADH	66..516	CDD:188167	241/452 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837840
Domainoid	1	1.000	488	1.000	Domainoid score	I384
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H840
Inparanoid	1	1.050	501	1.000	Inparanoid score	I1349
Isobase	1	0.950	-	0.930827	Normalized mean entropy	S643
OMA	1	1.010	-	-		QHG63174
OrthoDB	1	1.010	-	-		D899961at2759
OrthoFinder	1	1.000	-	-		FOG0003728
OrthoInspector	1	1.000	-	-		oto92406
orthoMCL	1	0.900	-	-		OOG6_102015
Panther	1	1.100	-	-	LDO	PTHR43353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1397
SonicParanoid	1	1.000	-	-		X2584
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750