DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and ALDH1L1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001257293.1	Gene:	ALDH1L1 / 10840	HGNCID:	3978	Length:	912	Species:	Homo sapiens

Alignment Length:	476	Identity:	181/476 - (38%)
Similarity:	279/476 - (58%)	Gaps:	10/476 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTAKDRSNLL 97
            :.|.:||:..|| |.|..||.:|:||.:|....|.|..||:.|||.|:|:..|..::|:||..|:
Human   436 IGGEFVDAEGAK-TSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLM 499

  Fly    98 KKWHKLIEQHSQEIAEIMTAESGKPINES-KGEVAYGNAFVEWFAEEARRIYGEIVP--SASPNR 159
            .:...|:|||.:|:|.|...::|.....: |..|........:||....:|.|..:|  .|.|||
Human   500 YRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNR 564

  Fly   160 EI-IVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLAVDAGIP 223
            .: :..|:|:||..:|.|||:|:.|::.|..|.||||.|||:||::.||||||..|:|.:.||||
Human   565 NLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIP 629

  Fly   224 KGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSA-DGIKRICLELGGNAPFIVF 287
            |||:||: ....:.:|......||||.|.|||||||||.:.::.| ..:|::.|||||.:|.|:|
Human   630 KGVVNVL-PGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIF 693

  Fly   288 DSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQGCDVQIGP 352
            ...|:.|||...|:|.|.|.|:.|::|.|.||:||::|:||.::.:.|..:|:|:....|...||
Human   694 ADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGP 758

  Fly   353 LINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVFGPVVSI 417
            ..:.....|:..:.:....:.|.::.||..:|..| .|:.||:.|||.....:..||.||||:.|
Human   759 QNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPG-FFFEPTVFTDVEDHMFIAKEESFGPVMII 822

  Fly   418 IRFRDEE-EAV-KKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAPFGGVKE 480
            .||.|.: :|| .:||.|..|||...::.::.:...|:.:|:.|.|.||....:...|||||.|:
Human   823 SRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQ 887

  Fly   481 SGVGREGSKHGIDDYVDIKYI 501
            ||.|::..:..:::|:.:|.:
Human   888 SGFGKDLGEAALNEYLRVKTV 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	174/460 (38%)
ALDH1L1	NP_001257293.1	Fmt	10..319	CDD:223301
		FMT_core_FDH_N	11..213	CDD:187716
		FDH_Hydrolase_C	216..316	CDD:187731
		PP-binding	335..401	CDD:278949
		ALDH_F1L_FTFDH	427..912	CDD:143458	181/476 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810