DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and aldh1l1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001185701.1	Gene:	aldh1l1 / 100526683	ZFINID:	ZDB-GENE-100519-4	Length:	903	Species:	Danio rerio

Alignment Length:	490	Identity:	166/490 - (33%)
Similarity:	281/490 - (57%)	Gaps:	10/490 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RMRGFSALVQDKALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESK 83
            ::...:..:..:..::|.:||:...| |::..||.:|..|..|....::|.:||:.|||:|:|..
Zfish   413 KLNNMTIHIPHQLFINGEFVDAEGGK-TYKSINPTDGQAICDVSLAQISDVEKAVAAAKEAFEEG 476

  Fly    84 EWRSLTAKDRSNLLKKWHKLIEQHSQEIAEIMTAESGKPINES-KGEVAYGNAFVEWFAEEARRI 147
            ||..:..:||..||.|...|:|||.:|:|.|.:.:||.....: |..:........:||....:|
Zfish   477 EWGKMNPRDRGKLLYKLADLMEQHQEELATIESIDSGAVYTLALKTHIGMSIQTFRYFAGWCDKI 541

  Fly   148 YGEIVP--SASPNREI-IVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLT 209
            .|..:|  .|.|||.: ...|:||||..::.|||:|:.|:..|..|.||||.|||:||::.||||
Zfish   542 QGCTIPINQARPNRNLTFTKKEPIGVCGIVIPWNYPLMMLAWKTAACLAAGNTVVLKPAQVTPLT 606

  Fly   210 ALAVAKLAVDAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSA-DGIKR 273
            ||..|:|...|..||||:|:: ....:.:|......||||.:.||||||:||.:.::.| ..:|:
Zfish   607 ALKFAELTALAKFPKGVVNIL-PGSGSLVGQRLSDHPDVRKLGFTGSTEIGKHIMKSCAVSNVKK 670

  Fly   274 ICLELGGNAPFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEAL 338
            :.|||||.:|.|:|:..|::|||...|:|.|.|.|:.|::|.|.|:::|::|.|:.::...:..:
Zfish   671 VSLELGGKSPLIIFNDCDLDKAVRMGMSSVFFNKGENCIAAGRLFIEESIHDIFLERVVSEIRKM 735

  Fly   339 KIGDGQGCDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSA 403
            ||||........||..::...:|:..:.|....:.|.::.||:.: ::...|:.||:.|||....
Zfish   736 KIGDPLDRSTDHGPQNHKAHLDKLVEYCEKGVKEGAKLVCGGKQV-ERPGFFFEPTVFTDVQDHM 799

  Fly   404 QLYSEEVFGPVVSIIRFRDEE--EAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEG 466
            .:..||.||||:.|.:|.:.|  :.:::||.|..|||...::.::.:...|:::|:.|.|.:|..
Zfish   800 YIAVEESFGPVMIISKFSNGEVDKVLQRANATEFGLASGVFTRDISKALYVSEKLQAGTVFINTY 864

  Fly   467 IISAAEAPFGGVKESGVGREGSKHGIDDYVDIKYI 501
            ..:...|||||.|:||.|::..:..:::|:..|.:
Zfish   865 NKTDVAAPFGGFKQSGFGKDLGQEALNEYLKTKCV 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	161/460 (35%)
aldh1l1	NP_001185701.1	Fmt	1..306	CDD:223301
		FMT_core_FDH_N	1..203	CDD:187716
		FDH_Hydrolase_C	206..307	CDD:187731
		ALDH_F1L_FTFDH	418..903	CDD:143458	166/485 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910