DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and aldh1l2

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_002938116.1	Gene:	aldh1l2 / 100127737	XenbaseID:	XB-GENE-5820495	Length:	922	Species:	Xenopus tropicalis

Alignment Length:	479	Identity:	171/479 - (35%)
Similarity:	285/479 - (59%)	Gaps:	10/479 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTAKDRS 94
            :..::|.:.|:.|.| |::..||.:|:||.||...:|||..||:.|||.|:|:.||..:.|:||.
Frog   443 QCFINGQFADADNGK-TYDTINPTDGSVICKVAYCSVADVDKAVAAAKDAFENGEWGKMNARDRG 506

  Fly    95 NLLKKWHKLIEQHSQEIAEIMTAESGKPINES-KGEVAYGNAFVEWFAEEARRIYGEIVP--SAS 156
            .:|.:...|:|:|.:|:|.|...:||.....: |..|........:||....:|.|..:|  .|.
Frog   507 RILYRLADLMEEHQEELATIEAIDSGAVYTLALKTHVGMSVQTFRYFAGWCDKIQGSTIPINQAR 571

  Fly   157 PNREI-IVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLAVDA 220
            |||.: ...|:|:||.|::.|||:|:.|:..|:.|.||||.|:|:||::.||||||..|:|||.|
Frog   572 PNRNLTFTKKEPLGVCAIVIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELAVKA 636

  Fly   221 GIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSA-DGIKRICLELGGNAPF 284
            |:||||||:: ......:|....:.||:|.:.|||||.:||.:.::.| ..:|::.|||||.:|.
Frog   637 GVPKGVINIL-PGSGGLVGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPL 700

  Fly   285 IVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQGCDVQ 349
            |:|:..|::|||...|.:.:.|.|:.|::|.|.||::|::|:||.::.:.::.::|||.......
Frog   701 IIFNDCDLDKAVRMGMGAVYFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMRIGDPLDRSTD 765

  Fly   350 IGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVFGPV 414
            .||..:.....|:..:.|....:.|.::.||:.:|..| .|..||:.|||.....|..||.|||:
Frog   766 HGPQNHRAHLEKLLEYCEIGVKEGATLVYGGRKVPRPG-FFMEPTVFTDVEDHMYLAEEESFGPI 829

  Fly   415 VSIIRFRDE--EEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAPFGG 477
            :.|.:|:|.  :..:::||:|..|||...:::::.:...|:::|:.|.|.:|....:...|||||
Frog   830 MVISKFKDGDIDGVLRRANNTEYGLASGVFTKDISKAMYVSEKLDAGTVFINTYNKTDVAAPFGG 894

  Fly   478 VKESGVGREGSKHGIDDYVDIKYI 501
            .|:||.|::..:..:.:|:..|.:
Frog   895 FKQSGFGKDLGEEALHEYLRTKAV 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	166/460 (36%)
aldh1l2	XP_002938116.1	FMT_core_FDH_N	23..225	CDD:187716
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..412	CDD:376348
		ALDH_F1L_FTFDH	437..922	CDD:143458	171/479 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000