Protein Alignment Npl4 and Npl4

DIOPT Version :10

• Sequence 1: NP_651407.3
• Gene: Npl4 / 43091
• FlyBaseID: FBgn0039348
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_550827.5
• Gene: Npl4 / 3290541
• VectorBaseID: AGAMI1_002311
• Length: 651
• Species: Anopheles gambiae
• Alignment Length: 659
• Identity: 395/659 - (59%)
• Similarity: 479/659 - (72%)
• Gaps: 59/659 - (8%)

  Fly    35 LIRVQSAEGIKRIEISPKSNLKHLYDSVQNALKVDG-----FGLFKERNFLTELQASGSQLV-GT 93
            ::|:|||:|.||||..|.|..|.||:.|:   :|.|     |.||:||||..|:.:||||.| ..
Mosquito     8 VLRIQSADGTKRIETEPSSTTKTLYELVR---EVCGFNHFEFALFRERNFTKEVVSSGSQEVKDV 69

  Fly    94 SLRHGDMVYLKQMAGTSSRRT---STTVLDSQAFKTSTISNPN---------SARPSFNVI---- 142
            .|:|||::||:.:.|.|:.:.   |.:|....:..:||.||.:         |::||.:..
Mosquito    70 GLKHGDILYLRLVEGPSTSKAAERSASVNSLASSHSSTFSNASFSREATPSTSSKPSTSAAAAAA 134

  Fly   143 ------------EDDVDQALSKADGTIKRERDSKLCHHNANGRCVHCSALEPYDESYLKEHNIKH 195
                        ||.||..|.|.||.|||:||.|||.||:||||||||||||:||:||||..|||
Mosquito   135 AAAATESSTIPQEDAVDLELYKQDGRIKRDRDEKLCRHNSNGRCVHCSALEPWDENYLKEQKIKH 199

  Fly   196 LSFHSYIRKQTSGMDQGKYFVFDDINCRIKPGCREHPPWPKGICSKCQPSAITLNRQTYRHVDNV 260
            .|||||::|.|||..:||:...:|:||:||.|||:||||||||||||||||||||||.|||||||
Mosquito   200 FSFHSYLKKLTSGAARGKFVALEDLNCKIKSGCRDHPPWPKGICSKCQPSAITLNRQPYRHVDNV 264

  Fly   261 MFENTKIVERFLNYWRTTGHQRMGYLYGTYEQHTDVPLGIRAKVAAIYEPPQESTRDSINIQPDE 325
            |||||.||||||||||||||||:|:|:|.||.|.||||||||:|||||||||||.||||.:..|.
Mosquito   265 MFENTGIVERFLNYWRTTGHQRIGFLFGKYEIHPDVPLGIRARVAAIYEPPQESNRDSIRLLDDP 329

  Fly   326 FADDVDAVASALGLKKIGWIFTDLITDDASIGTVKQIRGIESHFITAQECITAGELQNRHPNPCK 390
            ...|||.:|..|||:::|||||||::::.:.||||.:|.|::||:||||||.||.|||::||.||
Mosquito   330 HDADVDELARQLGLQRVGWIFTDLLSENLASGTVKHVRNIKTHFLTAQECILAGHLQNKYPNRCK 394

  Fly   391 YASNGVFGSKFVTICVTGDKTKQVHMEGYAVSAQCMALVRDNCLIPTKDAPELGYVRESTDKQYV 455
            .:|||.|||||||:|||||:.||||||||||||||||||||||||||||||||||:|||:|||||
Mosquito   395 DSSNGYFGSKFVTVCVTGDEKKQVHMEGYAVSAQCMALVRDNCLIPTKDAPELGYIRESSDKQYV 459

  Fly   456 PDVFYKEKDLYGNEVQRLARPLPVEYLLVDVPASTPLQPIYTFTE-YDKRQPFPIENRYIDGHLQ 519
            |||:|||||:||||||||.||||||||||||||||||.|:|||.| .|.:|.||:|||.||||:|
Mosquito   460 PDVYYKEKDVYGNEVQRLGRPLPVEYLLVDVPASTPLVPLYTFLERKDAKQYFPVENRMIDGHIQ 524

  Fly   520 DFNALSCYLSAWGEEEFLEAISDFHLLVYLYKM-DMLPLRQHMGPLLEAVRTKNPNQAAQFKVVD 583
            ||.||:.||:......||:|:||||||.|||:| ||||::..:||||||||.|:..:|.::|..:
Mosquito   525 DFAALANYLAKSRSLPFLDAVSDFHLLFYLYRMEDMLPMKSQLGPLLEAVRDKDKAKANEWKTRE 589

  Fly   584 VWKLLESLIQASSGGSGGTTS-----YPSGGASASAGASGSEAMDLDANTWTCNHCTFINRGELT 643
            |||.||.||:|||.....:.|     .|||.|.               ..|.|..|||||..||.
Mosquito   590 VWKTLEELIEASSNHDDSSMSNDVEFVPSGDAE---------------QNWICTFCTFINSRELP 639

  Fly   644 SCEICSLPR 652
            :||||:|||
Mosquito   640 ACEICNLPR 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npl4	NP_651407.3	UN_NPL4	35..105	CDD:431926	36/75 (48%)
		zf-NPL4	141..279	CDD:461523	103/153 (67%)
		NPL4	282..593	CDD:461524	216/312 (69%)
		ZnF_RBZ	627..651	CDD:197784	13/23 (57%)
		RanBP2-type Zn finger	629..648	CDD:275376	11/18 (61%)
Npl4	XP_550827.5	None