DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5071 and Ppid

DIOPT Version :9

Sequence 1:	NP_001303432.1	Gene:	CG5071 / 43090	FlyBaseID:	FBgn0039347	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_080628.1	Gene:	Ppid / 67738	MGIID:	1914988	Length:	370	Species:	Mus musculus

Alignment Length:	186	Identity:	51/186 - (27%)
Similarity:	82/186 - (44%)	Gaps:	42/186 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 PIYFLDMEIAGELAGRVLIEVRSDAAPRMADNFGALVRHERGYG--------YRGCTVFQAWGGE 570
            |..|.|::|.||..||:::|:.:|..|:.|:||.||...|:|.|        ::||...:.....
Mouse    16 PRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGTGSTTGKPLHFKGCPFHRIIKKF 80

  Fly   571 SIITGDFESQNGRGGHSAFESRYFLPDETGLPAHRGTVGMRRGQRRQDRSGFV----------GS 625
            .|..|||.:|||.||.|.:..::  .||.....|             ||.|.:          ||
Mouse    81 MIQGGDFSNQNGTGGESIYGEKF--EDENFHYKH-------------DREGLLSMANAGPNTNGS 130

  Fly   626 QFRLV---LNEMRSFTAIFGFIVQGI---ELVDRIAASGNALGRPALRSIIRNCGE 675
            ||.:.   ...:.....:||.:::|:   ..::.:..:|.   :||...:|..|||
Mouse   131 QFFITTVPTPHLDGKHVVFGQVIKGLGVARTLENVEVNGE---KPAKLCVIAECGE 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5071	NP_001303432.1	RING	16..59	CDD:238093
CG5071	NP_001303432.1	cyclophilin	514..674	CDD:294131	48/183 (26%)
Ppid	NP_080628.1	cyclophilin_ABH_like	16..182	CDD:238907	48/183 (26%)
		Chaperone activity. /evidence=ECO:0000250	185..215
		Interaction with HSP90AB1. /evidence=ECO:0000250	214..370
		TPR_11	223..304	CDD:290150
		TPR repeat	223..251	CDD:276809
		TPR repeat	272..302	CDD:276809
		TPR_11	277..338	CDD:290150
		TPR	277..306	CDD:197478
		TPR repeat	307..335	CDD:276809
		TPR_1	308..340	CDD:278916
		TPR repeat	341..364	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900