DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5071 and Trim17

DIOPT Version :9

Sequence 1:	NP_001303432.1	Gene:	CG5071 / 43090	FlyBaseID:	FBgn0039347	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_073635.1	Gene:	Trim17 / 64702	RGDID:	69290	Length:	477	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	77/427 - (18%)
Similarity:	145/427 - (33%)	Gaps:	120/427 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESIQVPKELKSLLSCGLCHRPYDLATGLLPQELACRHSFCKKCVQRNTDHNSSECICNLCGYRT 65
            |:::::.:.|:...:|.:|   .|..|.  |...||.|:||::|:|.:.:....:     .|.:.
  Rat     1 MDAVELARRLQEEATCSIC---LDYFTD--PVMTACGHNFCRECIQMSWEKGKGK-----KGKKK 55

  Fly    66 QLDGQQLPQSVTIMYLLRELPALILGRAMLDFSYKRSSTIEMSIEEAPSSPSKNWVEDINVESFL 130
            |......|:       .||:                             ||.:|...:..:....
  Rat    56 QKGSFPCPE-------CREM-----------------------------SPQRNLRPNRLLTKVA 84

  Fly   131 ATSAEH--------CFIHAMPNSTWCHNCQRLLCRACSDVPLHQDHILVRQVDYHDLISQLLNSE 187
            ..:.:|        |.||..|...:|.:.|..:|..|.:...|:.|.::...:........|..:
  Rat    85 EMARQHPGLHKRDLCQIHQEPLKLFCQDDQTPICVVCREAQEHRMHRVLPLDEAAREYKLRLEED 149

  Fly   188 LRKIKSTAVHAKELATHEMDLLRELCEACYRVQLHVKREMLEHHSSMVAASMIGWHR-----LAE 247
            ::.::...:..:.|...|...|.|     ::.::..:||.:......|...::...|     |.:
  Rat   150 IKYLREEMMKTETLQAKEEQTLTE-----WQERVKERRERILEEFQKVVLFLVEEERRLLQILKK 209

  Fly   248 RDLHRVGRLTGAKMLQVLAHLATQRQRYERQLDQVHFQCRMQAAIQENGMQVL-DFETLNNRIAR 311
            .:...:|:|..:|     |.|..|    .|.||.:..|...|.  |:..:|:| |.:....|...
  Rat   210 EEDDTLGKLQDSK-----ASLDHQ----SRSLDLILLQLEEQT--QQEPLQMLQDVKDTLTRKES 263

  Fly   312 LRSHRRPGAIPANVG-----PPQALILTNYCVYAYWCEMQREMIPPRHRNLTPDPELLPEPRRAV 371
            |........:|..:.     |.|..:|.::                       ..:::|:|..|
  Rat   264 LSMQYPEVVLPVAIKTVCRVPGQIEVLKSF-----------------------QEDVVPDPSTA- 304

  Fly   372 VPPHFNNSLREVELLDYVQQIELEQFRTLSQPPYDGS 408
                          ..|:...|..|.|.||.|| :||
  Rat   305 --------------YPYLLLYESRQRRYLSPPP-EGS 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5071	NP_001303432.1	RING	16..59	CDD:238093	12/42 (29%)
CG5071	NP_001303432.1	cyclophilin	514..674	CDD:294131
Trim17	NP_073635.1	RING	16..65	CDD:302633	15/65 (23%)
		BBOX	94..135	CDD:197662	10/40 (25%)
		Spore_III_AB	<134..245	CDD:298618	21/126 (17%)
		SPRY_PRY_TRIM17	296..472	CDD:293984	13/47 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	47	1.000	Inparanoid score	I5392
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050