DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5071 and Trim35

DIOPT Version :9

Sequence 1:	NP_001303432.1	Gene:	CG5071 / 43090	FlyBaseID:	FBgn0039347	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001020313.2	Gene:	Trim35 / 498538	RGDID:	1564642	Length:	515	Species:	Rattus norvegicus

Alignment Length:	361	Identity:	76/361 - (21%)
Similarity:	120/361 - (33%)	Gaps:	119/361 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KELKSLLSCGLCHRPY-DLATGLLPQELACRHSFCKKCVQRNTDHNSSEC-------ICNLCGYR 64
            :..|..|.|.:|:.|: |..|      |.|.|:||::||        |.|       .|.:|..|
  Rat    27 RSFKEELLCAVCYDPFRDAVT------LRCGHNFCRRCV--------SGCWEVQTTPSCPVCKER 77

  Fly    65 TQLDGQQLPQSVTIMYLLRELPALILGRAMLDFSYKRSSTIEMSIEEAPSSPSKNWVEDINVESF 129
            .      :|..:...:.|..|...:|.                  |||..:   .|..
  Rat    78 A------VPGELRTNHTLNNLVETLLR------------------EEAEGA---RWTG------- 108

  Fly   130 LATSAEHCFIHAMPNSTWCHNCQRLLCRACSDVPLHQDHILVRQVDYHDLISQLLNSELRKIKST 194
             ..|...|..|..|.:.:|...:.|||.||.....||:|                  .::.||.|
  Rat   109 -RRSPRPCRAHRAPLTLFCVEDKELLCCACQADARHQEH------------------RVQPIKDT 154

  Fly   195 AVHAKELATHEMDLLRELCEACYRVQLHVKREMLEHHSSMVAASMIGWHRLAE-----RDLHRVG 254
            |...:....:...:|||..::.:  .|....|.:..|:.:....:.|  |:.:     ||..||.
  Rat   155 AQDFRAKCKNMEHVLREKAKSFW--ALRRTYEAIAKHNEVQTTWLEG--RIRDEFDKLRDFLRVE 215

  Fly   255 R----------------LTGAKMLQVLAHLATQRQRYERQLDQVHFQCRMQAAIQENGMQVLDFE 303
            .                |...||.|    ||.|.:...|:::      |:|..::|:.|..|
  Rat   216 EQATVDAMKEESRKKHLLAEEKMKQ----LAEQTEALAREIE------RLQMEMKEDDMTFL--- 267

  Fly   304 TLNNRIARLRSHRRPGAIPANVGPPQALILTNYCVY 339
                  .:.:|.:|.........|.|..:|.:.|.|
  Rat   268 ------MKHKSRKRRLFCTVEPAPLQPGLLMDACKY 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5071	NP_001303432.1	RING	16..59	CDD:238093	14/50 (28%)
CG5071	NP_001303432.1	cyclophilin	514..674	CDD:294131
Trim35	NP_001020313.2	RING	35..76	CDD:238093	16/54 (30%)
		BBOX	113..151	CDD:237988	12/55 (22%)
		DUF4200	<198..261	CDD:290574	16/74 (22%)
		SPRY	317..503	CDD:295394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	47	1.000	Inparanoid score	I5392
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050