DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5071 and ppil2

DIOPT Version :9

Sequence 1:	NP_001303432.1	Gene:	CG5071 / 43090	FlyBaseID:	FBgn0039347	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_957285.2	Gene:	ppil2 / 393966	ZFINID:	ZDB-GENE-040426-1096	Length:	524	Species:	Danio rerio

Alignment Length:	297	Identity:	58/297 - (19%)
Similarity:	105/297 - (35%)	Gaps:	87/297 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 HFNNSLREVELLDYVQQIELEQFRTLSQPPYDGSHESSSSPNSSSSTNSQSNYIALDTEYGLREL 439
            |..|:::   :||               |..:.:.:..|....|::..::.....|..:|...||
Zfish   174 HVKNNMK---VLD---------------PDEEKAKQDPSYHLKSTNLETRETLAELYRDYKGDEL 220

  Fly   440 VRQLQQQPQQVQQEQQQQQQQVHQLTHSI--------------YQPDAILVNSVEPQLIGQQSHD 490
            :....::|   :.::..:....|..|..:              ::.|||..::|..|.:.::.:.
Zfish   221 LASTMKEP---EAKKTDKFNAAHYSTGRVSASFTSTAMAPATNHEADAIADDAVRYQYVKKKGYV 282

  Fly   491 H-HRQDGGTSSSVSIVRQPIVHCYPIYFLDMEIAGELAGRVLIEVRSDAAPRMADNFGALVRHER 554
            . |...|..:                                :|:..|..|:..:||..|.:  :
Zfish   283 RLHTNKGDLN--------------------------------VELHCDKVPKAGENFIKLCK--K 313

  Fly   555 GYGYRGCTVFQAWGGESIITGDFESQNGRGGHSAFESRY---FLPD--ETGLPAHRGTVGMRRGQ 614
            || |.| |||.......:|.|...:..|.||.|.:...:   |.|:  .||    ||.:.|....
Zfish   314 GY-YDG-TVFHRSIRNFMIQGGDPTGTGTGGESFWGKPFKDEFRPNLSHTG----RGILSMANSG 372

  Fly   615 RRQDRSGFVGSQFR--LVLNEMRSFTAIFGFIVQGIE 649
            ...::|.|. ..||  ..|:...|   :||.:|.|:|
Zfish   373 PNTNKSQFF-ITFRSCAYLDRKHS---VFGRVVGGLE 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5071	NP_001303432.1	RING	16..59	CDD:238093
CG5071	NP_001303432.1	cyclophilin	514..674	CDD:294131	37/143 (26%)
ppil2	NP_957285.2	Ubox	42..96	CDD:128780
ppil2	NP_957285.2	cyclophilin_RING	281..440	CDD:238904	39/169 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900