DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5071 and Trim62

DIOPT Version :9

Sequence 1:	NP_001303432.1	Gene:	CG5071 / 43090	FlyBaseID:	FBgn0039347	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_038967455.1	Gene:	Trim62 / 313045	RGDID:	1586169	Length:	475	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	109/476 - (22%)
Similarity:	168/476 - (35%)	Gaps:	151/476 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LKSLLSCGLCHRPYDLATGLLPQELACRHSFCKKCVQRNTDHNSSECICNLCGYRTQLDGQQLPQ 74
            ||..|.|.:|...|.     .|..|.|.|.||::|:   |:|          ..|.:..|
  Rat     5 LKDELLCSICLSIYQ-----DPVSLGCEHYFCRRCI---TEH----------WVRQEAQG----- 46

  Fly    75 SVTIMYLLRELPALILGRAMLDFSYKRSSTIEMSIEEAPSSPSKNWVEDIN---VESFL--ATSA 134
                   .|:.|..            |.:..|.::  |||....|.||..:   :::.|  ..:|
  Rat    47 -------ARDCPEC------------RRTFAEPAL--APSLKLANIVERYSAFPLDAILNARRAA 90

  Fly   135 EHCFIHAMPNSTWCHNCQRLLCRACSDVPLHQDHILVRQVDYHDLISQLLNSELRKIKSTAVHAK 199
            ..|..|... ..:|...:.|||..|.:..||:.|.:....|..:.:.:.|..:|:.::.:|
  Rat    91 RPCQAHDKV-KLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFEELQRELKEQLQALQDSA---- 150

  Fly   200 ELATHEMDLLRELCEACYRVQLHVKREMLEHHSSMVA-ASMIGWHRLAERDLHRVGRLTGAKMLQ 263
                      ||..||   :|| :||::.|..||..: .:.||  ...|| |||:.|.....||:
  Rat   151 ----------REHTEA---LQL-LKRQLAETKSSTKSLRTTIG--EAFER-LHRLLRERQKAMLE 198

  Fly   264 --------VLAHLATQRQRYERQLDQVH------------------------FQCRMQAAIQENG 296
                    .|..:..:.|||.:||.:|.                        ...|::....|..
  Rat   199 ELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKTHETN 263

  Fly   297 MQVLDFET------LNNRIAR---LRSHRRPGAIPANVGPP-QALILTNYC-VYAYWCEMQREMI 350
            :...||.|      |...|.:   ...|..|.|:..:.|.. |.|||::.| :.||
  Rat   264 LTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAY--------- 319

  Fly   351 PPRHRNLTPDPELLPEPRRAVVPPHFNNSLREVELL---------DYVQQIELEQFRTLSQPPYD 406
                .||.|.| |...|:|..|         ||.:|         .|.:.:..|:    :|....
  Rat   320 ----GNLHPQP-LQDSPKRFDV---------EVSVLGSEAFSSGVHYWEVVVAEK----TQWVIG 366

  Fly   407 GSHESSSSPNSSSSTNSQSNY 427
            .:||::|...|.....|:..|
  Rat   367 LAHEAASRKGSIQIQPSRGFY 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5071	NP_001303432.1	RING	16..59	CDD:238093	12/42 (29%)
CG5071	NP_001303432.1	cyclophilin	514..674	CDD:294131
Trim62	XP_038967455.1	RING-HC_TRIM62_C-IV	6..55	CDD:319522	18/90 (20%)
		Bbox2_TRIM62_C-IV	91..128	CDD:380850	10/37 (27%)
		BBC	136..255	CDD:128778	31/139 (22%)
		SPRY_PRY_TRIM62	284..471	CDD:293978	31/131 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	47	1.000	Inparanoid score	I5392
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050