DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5071 and Fsd2

DIOPT Version :9

Sequence 1:	NP_001303432.1	Gene:	CG5071 / 43090	FlyBaseID:	FBgn0039347	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001178556.1	Gene:	Fsd2 / 308779	RGDID:	1305167	Length:	746	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	84/459 - (18%)
Similarity:	144/459 - (31%)	Gaps:	126/459 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 DFSYKRS---STIEMSIEEAPSSPSKNWV----EDINVESFLATSAEHCFIHAMPNSTWCHNCQR 153
            ||...:.   :.|..::|.|.....||..    :.|.:|:| |:..|..||....|  :....|.
  Rat   189 DFDIHKEHEVTPINKALEHAKDEIHKNMCKLEQQIIEMENF-ASHLEEVFITVEEN--FGRQEQN 250

  Fly   154 LLCRACSDVPLHQDHILVRQVD-YHDLISQLLNSELRKIKSTAVHAKELATHE-MDLLRELCEAC 216
            ..|        |.:.||..... |.:.|..|  .|.:|.|..|::.:.::..| :|..|||.|..
  Rat   251 FEC--------HYNEILETLAQKYEEKIQAL--GEKKKEKLEALYGQLVSCGENLDACRELMETI 305

  Fly   217 YRVQLHVKREMLEHHSSMVAASMIGWHRLAERDLHRVGRLTGAKMLQVLAHLATQRQRYERQLDQ 281
            ..:....|.:.|:...:|.               .|:|:....|....|
  Rat   306 EEMCHEEKVDFLKDAVAMT---------------DRLGKFLKTKTDVEL---------------- 339

  Fly   282 VHFQCRMQAAIQENGMQVLDFETLNNRIARLRSHRRPGAIPANVGPPQALILTNYCVYAYWCEMQ 346
                    :|..|...|.|||..:...:..:.:...|.|...|...|.:  .|...|...|....
  Rat   340 --------SAKPEFEDQTLDFSDVEQLMDSINTVPAPSAPVINPQAPNS--ATGSSVRVCWSLYS 394

  Fly   347 REMIPPRHRNLTPDPELLPEPRRAVVPPHFNNSLREVELLDYVQQIELE-----QFRTLSQPPYD 406
            .:.:.....:..|..:..|...:|    .|..:::|.    |.....||     :|..::|
  Rat   395 DDTVESYQLSYRPVQDSSPGKDQA----EFTMTVKET----YCSVKNLEPNTQYEFWVIAQ---- 447

  Fly   407 GSHESSSSPNSSSSTNSQSNYIALDTEYGLRELVRQLQQQPQQVQQEQQQQQQQVHQLTHSIYQP 471
              :.:..||:|                   ..:|......|..::.|..:..:
  Rat   448 --NRTGPSPSS-------------------EHVVYMTAPSPPSIKTEAIRSCE------------ 479

  Fly   472 DAILV-------NSVEPQLIGQQSHDHHRQDGGTSSSV------SIVRQPIVHCYPIYFLDMEIA 523
            :|:|:       |.|:...:.....:.....|.|.|.|      |:::....|.|.||...:.:.
  Rat   480 EAVLICWESGNLNPVDSYTVELIQAETPEASGVTESVVGIPTCESLIQLQPRHSYTIYVRALNVG 544

  Fly   524 GELA 527
            |..|
  Rat   545 GTSA 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5071	NP_001303432.1	RING	16..59	CDD:238093
CG5071	NP_001303432.1	cyclophilin	514..674	CDD:294131	4/14 (29%)
Fsd2	NP_001178556.1	PRK12704	203..>307	CDD:237177	30/116 (26%)
		FN3	368..453	CDD:214495	17/100 (17%)
		FN3	465..557	CDD:238020	17/96 (18%)
		SPRY	561..737	CDD:413402
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	47	1.000	Inparanoid score	I5392
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050