DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5071 and Trim31

DIOPT Version :9

Sequence 1:	NP_001303432.1	Gene:	CG5071 / 43090	FlyBaseID:	FBgn0039347	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001099846.1	Gene:	Trim31 / 294208	RGDID:	1308607	Length:	507	Species:	Rattus norvegicus

Alignment Length:	356	Identity:	63/356 - (17%)
Similarity:	123/356 - (34%)	Gaps:	118/356 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESIQVPKELKSLLSCGLCHRPYDLATGLLPQELACRHSFCKKCVQRNTDHNSSECICNLCGYRT 65
            |...::..:|:..::|.:|     |.....|..:.|.|:||.||:.: ....|...:|.||
  Rat     1 MADPKMASQLQEDVTCPIC-----LEILQDPVTIDCGHNFCLKCINQ-IGKTSENILCPLC---- 55

  Fly    66 QLDGQQLPQSVTIMYLLRELPALILGRAMLDFSYKRSSTIEMSIEEAPSSPSKNWVEDINVESFL 130
                                                    :.|:.:....|:|          .|
  Rat    56 ----------------------------------------KCSVSKNTFRPNK----------LL 70

  Fly   131 ATSAE-----------------HCFIHAMPNSTWCHNCQRLLCRACSDVPLHQDHILVRQVDYHD 178
            |:.||                 .|..|......:|.....|||..|.|   .:||      .:||
  Rat    71 ASLAEKIQTMDPADIQQEKEEARCQKHKKKLYYFCEQDGALLCVVCRD---SKDH------KFHD 126

  Fly   179 --LISQLLNSELRKIKSTAVHAKELATHEMDLLRELCEA-----CYRVQLHV-KREMLEHHSSMV 235
              ||.:.:.:...:|:|   .|::|...:.:::.|....     .:|.|:.: |.:::|....:
  Rat   127 VTLIDEAVQNYKVQIES---QAQDLGRKDKEIIEEKKRGEGAIWTFRAQVELEKLKVIEEFKHL- 187

  Fly   236 AASMIGWHRLAERDLHRVGRL-----TGAKMLQVLAHLATQRQRYERQLDQVHFQCR-MQAAIQE 294
                  ..||.|.:...:.|:     .|||.|.....:.      |:||:.:....: ::..:|.
  Rat   188 ------RQRLDEEESFLLSRMDWLEKQGAKQLGQYVTVT------EKQLNSLRTLTKSLKIRLQS 240

  Fly   295 NGMQVLDFETLNNRIARLRSHRRPGAIPANV 325
            :.:::|  :.:.:.::|.:..:....||..|
  Rat   241 SSIELL--KDIKDTLSRNKEFQFLSPIPVPV 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5071	NP_001303432.1	RING	16..59	CDD:238093	11/42 (26%)
CG5071	NP_001303432.1	cyclophilin	514..674	CDD:294131
Trim31	NP_001099846.1	zf-C3HC4_4	16..55	CDD:291880	12/44 (27%)
		zf-B_box	89..130	CDD:279037	12/49 (24%)
		Phage_Mu_Gam	163..>274	CDD:295047	21/122 (17%)
		SPRY	335..505	CDD:295394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	47	1.000	Inparanoid score	I5392
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050