DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5071 and Trim6

DIOPT Version :9

Sequence 1:	NP_001303432.1	Gene:	CG5071 / 43090	FlyBaseID:	FBgn0039347	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001163932.1	Gene:	Trim6 / 293294	RGDID:	1310896	Length:	488	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	111/560 - (19%)
Similarity:	211/560 - (37%)	Gaps:	162/560 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ELKSLLSCGLCHRPYDLATGLLPQELACRHSFCKKCVQRNTDHN----SSECICNLCGYRTQLDG 69
            :::..::|.:|   .:|.|.  |..:.|.||||:.|:..|:|::    ..:..|.:|  ||....
  Rat     8 DIRDEVTCPIC---LELLTE--PLSIDCGHSFCQACIIGNSDNSVLNPEGKSSCPVC--RTVYQP 65

  Fly    70 QQLPQSVTIMYLLRELPALILGRAMLDFSYKRSSTIEMSIEEAPSSPSKNWVEDINVESFLATSA 134
            ..|..:..:..:::.|..::||                        |.|. :|.|
  Rat    66 GSLRPNRHLAAIVKRLREVVLG------------------------PGKQ-LEVI---------- 95

  Fly   135 EHCFIHAMPNSTWCHNCQRLLCRACSDVPLHQDH--ILVRQV--DYHDLISQLLNSELRKIKSTA 195
             .|.:|......:|....:|:|..|.....|:.|  .|:.:|  :|.|:..:    .|:|::...
  Rat    96 -FCALHGEKLQLFCKEDGKLICWLCERSLEHRGHHTFLMEEVAQEYQDMFQE----SLKKLRREQ 155

  Fly   196 VHAKELATHEMDLLRELCEACYRVQLHVKREMLEHHSSMVAASMIGWHRLAERDLHRVGRLTGAK 260
            ..|::|..    |::|..|: ::.|:..:|..::...:.:.:.:   .|..:|:|.:: .:...|
  Rat   156 QEAEKLKA----LIQEKRES-WKSQVEPERHRIQTEFNQLRSIL---DREEQRELKKL-EVEERK 211

  Fly   261 MLQVL----AHLATQRQRYERQLDQVHFQCRMQAA--IQENG--MQVLDFETLNNRIARLRSHRR 317
            .|.|:    ..|..|.|..:..:..:..:||....  :|:.|  .:..:|.||          ::
  Rat   212 GLSVIEKAEGDLIHQSQALKDLISDLEHRCRGSTVELLQDVGDVTKRSEFWTL----------KK 266

  Fly   318 PGAIPANV-----GPPQALILTNY----CVYAYWCEMQREMIPPRHRNLTPDPELLPEPRRAV-- 371
            |.|:|..:     .|....:|..:    .|.:||.::   .:.|:..||.   .:|.:.||.|
  Rat   267 PQALPTKLKSLFRAPDLKKMLRVFRELTDVQSYWVDV---TLNPQTANLN---LVLSKNRRQVRF 325

  Fly   372 ----------VPPHFNNSLR------------EVELLDYVQQIELEQFRTLSQPPYDGSHESSSS 414
                      :..|::.|:.            ||::......| |....|..:|.:..| :.||.
  Rat   326 VGAKLSEPSSLEEHYDCSVLGSQHFSSGKYYWEVDVTKKTAWI-LGVCSTPVEPMFSFS-QYSSK 388

  Fly   415 PNSSSSTNSQSNYIALDTEYGLRELVRQLQQQPQQVQQEQQQQQQQVHQLTHSIYQ---PDAILV 476
            ..:.|....||.|..:    ||                      |:.|:  :..|:   |..:|.
  Rat   389 QGAYSRYQPQSGYWVI----GL----------------------QRKHE--YRAYEDSSPSLLLS 425

  Fly   477 NSVEPQLIGQQSHDHHRQDGGTSSSVSIVRQPIVHCYPIY 516
            .:|.|:.|| ...|:   :.||.|..::..    |..|||
  Rat   426 MTVPPRRIG-VFLDY---EAGTVSFYNVTN----HGLPIY 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5071	NP_001303432.1	RING	16..59	CDD:238093	13/46 (28%)
CG5071	NP_001303432.1	cyclophilin	514..674	CDD:294131	3/3 (100%)
Trim6	NP_001163932.1	RING-HC_TRIM5_like-C-IV	12..61	CDD:319505	15/55 (27%)
		Bbox2_TRIM5-like	97..134	CDD:380819	9/36 (25%)
		SMC_prok_B	147..>240	CDD:274008	18/101 (18%)
		SPRY_PRY_TRIM6	299..486	CDD:293995	43/203 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	47	1.000	Inparanoid score	I5392
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050