DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5071 and PPIL6

DIOPT Version :9

Sequence 1:	NP_001303432.1	Gene:	CG5071 / 43090	FlyBaseID:	FBgn0039347	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001104768.2	Gene:	PPIL6 / 285755	HGNCID:	21557	Length:	337	Species:	Homo sapiens

Alignment Length:	412	Identity:	89/412 - (21%)
Similarity:	131/412 - (31%)	Gaps:	135/412 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 AIPANVGPPQALI---------LTNYCVYAYWC------EMQREMIPPRHRNLTPDPELLPEPRR 369
            |.|...|||.|..         |....|..:.|      :...|.:...|.:...||.|:|
Human     2 ARPQPCGPPHARCGSPSLPERPLQVKVVGLFSCPNFQIAKSAAENLKNNHPSKFEDPILVP---- 62

  Fly   370 AVVPPHFNNSLREVELLDYVQQIELEQFRTLSQPPYDGSHESSSSPNSSSSTNSQSNYIALDTEY 434
                      |:|.....|:|    |:.|.|....:    |.|||  ..|..|.|....|||.
Human    63 ----------LQEFAWHQYLQ----EKKRELKNETW----EYSSS--VISFVNGQFLGDALDL-- 105

  Fly   435 GLRELVRQLQQQPQQVQQEQQQQQQQVHQLTHSI-YQPDAI---LVNSVEPQLIGQQSHDHHRQD 495
                                   |:..|::...: .:|.|:   |......:.:....||
Human   106 -----------------------QKWAHEVWDIVDIKPSALYDALTEDFSAKFLRDTKHD----- 142

  Fly   496 GGTSSSVSIVRQPIVHCYPIYFLDMEIAGELAGRVLIEVRSDAAPRMADNFGALVRHERGYGYRG 560
                               ..|||:.|.....||::.|:..|..|:...||..|...:.|:..||
Human   143 -------------------FVFLDICIDSSPIGRLIFELYCDVCPKTCKNFQVLCTGKAGFSQRG 188

  Fly   561 C------TVF-----QAW------------GGESIITGDFESQNG---RGGHSAFESR------Y 593
            .      ::|     ..|            .||||....||...|   |......|||      .
Human   189 IRLHYKNSIFHRIVQNGWIQGGDIVYGKGDNGESIYGPTFEELYGSLKRSVKRQKESRGVGKIEK 253

  Fly   594 FLPDETGLPAH-RGTVGMRRGQRRQDRSGFVGSQFRLVLNEM----RSFTAIFGFIVQGIELVDR 653
            :..:...:|.: ||.:||....|..:     ||||.:.|...    |.|.| ||.:::|.|::.:
Human   254 YRDENFSVPHNKRGVLGMANKGRHSN-----GSQFYITLQATPYLDRKFVA-FGQLIEGTEVLKQ 312

  Fly   654 IAASGNALGRPALRSIIRNCGE 675
            :........||.....|.:.|:
Human   313 LELVPTQNERPIHMCRITDSGD 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5071	NP_001303432.1	RING	16..59	CDD:238093
CG5071	NP_001303432.1	cyclophilin	514..674	CDD:294131	49/196 (25%)
PPIL6	NP_001104768.2	cyclophilin	144..333	CDD:412213	49/194 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900