Protein Alignment CG5071 and TRIM35

DIOPT Version :9

• Sequence 1: NP_001303432.1
• Gene: CG5071 / 43090
• FlyBaseID: FBgn0039347
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: NP_741983.2
• Gene: TRIM35 / 23087
• HGNCID: 16285
• Length: 493
• Species: Homo sapiens
• Alignment Length: 586
• Identity: 116/586 - (19%)
• Similarity: 185/586 - (31%)
• Gaps: 201/586 - (34%)

  Fly     8 KELKSLLSCGLCHRPY-DLATGLLPQELACRHSFCKKCVQRNTDHNSSECICNLCGYRTQLDGQQ 71
            :..|..|.|.:|:.|: |..|      |.|.|:||:.||.|..:...|. .|.:|..|..
Human    13 RSFKEELLCAVCYDPFRDAVT------LRCGHNFCRGCVSRCWEVQVSP-TCPVCKDRAS----- 65

  Fly    72 LPQSVTIMYLLRELPALILGRAMLDFSYKRSSTIEMSIEEAPSSPSKNWVEDINVESFLATS--- 133
             |..:...:.|..|...:|.                  |||..:   .|           ||
Human    66 -PADLRTNHTLNNLVEKLLR------------------EEAEGA---RW-----------TSYRF 97

  Fly   134 AEHCFIHAMPNSTWCHNCQRLLCRACSDVPLHQDHILVRQVD-YHDLISQLLNSELRKIKSTAVH 197
            :..|.:|....|.:|...:.|||.:|...|.||.|.:....| .||..::..|.|         |
Human    98 SRVCRLHRGQLSLFCLEDKELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNME---------H 153

  Fly   198 AKELATHEMDLLRELCEACYRVQLHVKREMLEHHSSMVAASMIGWHRLAERDLHRVGRLTGAKML 262
            |          |||..:|.:.::.  ..|.:..|:.:.||.:.|..|.....|....|:....:|
Human   154 A----------LREKAKAFWAMRR--SYEAIAKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAIL 206

  Fly   263 QVLAHLATQRQRYERQLDQVHFQCRMQAAIQENGMQVLDFETLNNRIARLRSH----RRPGAIPA 323
            ..:|....|:|..   .|:...|...:..:..:.::.|..|...:.::.|..|    ||
Human   207 DAMAEETRQKQLL---ADEKMKQLTEETEVLAHEIERLQMEMKEDDVSFLMKHKSRKRR------ 262

  Fly   324 NVGPPQALILTNYCVYAYWCEMQREMIPPRHRNLTPDPELLPEPRRAVVPPHFNNSLREVELLDY 388
                             .:|.|:                  |||    |.|..        |:|.
Human   263 -----------------LFCTME------------------PEP----VQPGM--------LIDV 280

  Fly   389 VQQIELEQFR-------TLSQPPYDGSHESSSSPNSSSSTNSQSNYIALDTEYGLRELVRQLQQQ 446
            .:.:...|:|       ::...|:      |..||:::...|.|:.:...|.:|.|
Human   281 CKYLGSLQYRVWKKMLASVESVPF------SFDPNTAAGWLSVSDDLTSVTNHGYR--------- 330

  Fly   447 PQQVQQEQQQQQQQVHQLTHSIYQPDAILVNSVEPQLIGQQSHDHHRQDGGTSS-SVSIVRQPIV 510
               ||.|..::           :.....|:.|   ::..|.||......||..| .|.:||
Human   331 ---VQVENPER-----------FSSAPCLLGS---RVFSQGSHAWEVALGGLQSWRVGVVR---- 374

  Fly   511 HCYPIYFLDMEIAGELAGRVLIEVRSDAAPRMADNFGALVRHERGYGYRGCTVFQAWGGESIITG 575
                                   ||.|:.   |:.......|:...|:......|...|:..:|.
Human   375 -----------------------VRQDSG---AEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTS 413

  Fly   576 D 576
            |
Human   414 D 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5071	NP_001303432.1	RING	16..59	CDD:238093	14/43 (33%)
		cyclophilin	514..674	CDD:294131	10/63 (16%)
TRIM35	NP_741983.2	RING-HC_TRIM35_C-IV	18..62	CDD:319513	17/50 (34%)
		RING-HC finger (C3HC4-type)	21..60	CDD:319513	15/45 (33%)
		Bbox_SF	96..139	CDD:381767	12/42 (29%)
		DUF4200	151..247	CDD:372763	23/119 (19%)
		SPRY_PRY_TRIM35	303..482	CDD:293950	33/174 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910