DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5071 and XB5765006

DIOPT Version :9

Sequence 1:	NP_001303432.1	Gene:	CG5071 / 43090	FlyBaseID:	FBgn0039347	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_002941622.2	Gene:	XB5765006 / 100489074	XenbaseID:	XB-GENE-5765007	Length:	521	Species:	Xenopus tropicalis

Alignment Length:	516	Identity:	91/516 - (17%)
Similarity:	163/516 - (31%)	Gaps:	169/516 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LKSLLSCGLCHRPY-DLATGLLPQELACRHSFCKKCVQRNTDHNSSECICNLCGYRTQLDGQQLP 73
            |...|:|.:|...| |      |..|.|.|:||..|:....|..:...|
Frog     6 LNDELTCSICLSIYKD------PVMLPCGHNFCDHCIVHTMDSQTGSGI---------------- 48

  Fly    74 QSVTIMYLLRELPALILGRAMLDFSYKRSSTIEMSIEEAPSSPSKNWVEDINVESFLATSAEHCF 138
                  |...|..|:...|..|..:.|.|:.:|..:...|        ::...|.|    ..:|.
Frog    49 ------YTCPECRAVFKQRPSLQKNLKLSNIVERYLCTQP--------KETKSEVF----CSYCI 95

  Fly   139 IHAMPNSTWCHNCQRLLCRACSDVPL-----HQDHILVRQVDYHDLISQ-LLNSELRKI---KST 194
            ...:.....|.:|:..:|    |:.|     .:.|:|:....:.:..:: |:::||.|.   :.:
Frog    96 ASPVLAVKTCLHCEASMC----DMHLTTHSKSEKHVLIEPTAFKEEGNKCLIHNELLKYFCPQDS 156

  Fly   195 AVHAKELATHEMDLLRELCEACYRVQLHVKREMLEHHSSMVAASMIGWHRLAERDLHRVGRLTGA 259
            |:               :|.:|.:...|      ..||         |..::  |.....:.|
Frog   157 AL---------------ICLSCSKEGKH------HRHS---------WELIS--DAFEKKKTT-- 187

  Fly   260 KMLQVLAHLATQRQRYERQLDQVHFQCRMQAAIQENGMQVLDFETLNNRIARLRSHRRPGAIPAN 324
             :|..|..|..:|...::||..:     .:...:|.|..    ..:..|:|.|.|..|
Frog   188 -LLDFLQKLNLRRTENQKQLSML-----QERKKKEEGRA----SDMKERVAALFSDIR------- 235

  Fly   325 VGPPQALILTNYCVYAYWCEMQREMIPPRHRNLTPDPELLPEPRRAVVPPHFNNSLREVELLD-Y 388
               .:.|.|.|..:        .|:|....:...|..:|:..              .|:|..| |
Frog   236 ---EEVLALENKVI--------NEIIRQEEKVSHPLADLIQR--------------FEIEKADLY 275

  Fly   389 VQQIELEQFRTLSQP------PYDGSHESSSSPNSSSSTNSQSNYIALDTEYGLRELVRQLQQQP 447
            .::..:|:..::..|      |...|.........:..:|.....|.:..:.||..|...:.:.
Frog   276 AKKCHIEKLCSVKDPLTLLKQPAITSDLGKKHLEVADISNFDGLTIDVTLQKGLSRLTDTIPKL- 339

  Fly   448 QQVQQEQQQQQQQVHQLTHSIY---QPDAIL-VNSVEPQLI------------GQQSHDHH 492
                           :|:...|   :.|.|| ||:.:|.:.            .:.|..||
Frog   340 ---------------KLSRGFYTEDESDMILNVNTADPNIALSPHLRRASYCQNEVSRPHH 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5071	NP_001303432.1	RING	16..59	CDD:238093	13/43 (30%)
CG5071	NP_001303432.1	cyclophilin	514..674	CDD:294131
XB5765006	XP_002941622.2	RING_Ubox	9..55	CDD:388418	16/73 (22%)
		Bbox_SF	91..131	CDD:381767	8/43 (19%)
		Bbox_SF	141..182	CDD:381767	12/72 (17%)
		BBC	184..294	CDD:128778	27/153 (18%)
		SPRY_PRY_C-I_2	353..519	CDD:293949	8/33 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	44	1.000	Inparanoid score	I5302
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050