Protein Alignment msi and NAM8

DIOPT Version :10

• Sequence 1: NP_733108.2
• Gene: msi / 43087
• FlyBaseID: FBgn0011666
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: NP_011954.1
• Gene: NAM8 / 856486
• SGDID: S000001128
• Length: 523
• Species: Saccharomyces cerevisiae
• Alignment Length: 487
• Identity: 99/487 - (20%)
• Similarity: 155/487 - (31%)
• Gaps: 168/487 - (34%)

  Fly    81 GLIDPHHNRDLHQALVASI--ANNSVAAIGGGLTTAAVLKSAAQQSQQAVQQNQNAVVVTPGLEQ 143
            |.:||..:::..:.:.||:  ||.:|..:.....      :...:|....:.||....|    :.
Yeast    59 GDLDPTWDKNTVRQIWASLGEANINVRMMWNNTL------NNGSRSSMGPKNNQGYCFV----DF 113

  Fly   144 PKQEPAQQAALALLKENVNASAGAGQNNGQAAMGGSNKSGSSGRSTPSLSGGSGS--DPAPG--- 203
            |.   :..||.||||            ||.......||......:|.|.|..:.|  :...|
Yeast   114 PS---STHAANALLK------------NGMLIPNFPNKKLKLNWATSSYSNSNNSLNNVKSGNNC 163

  Fly   204 KLFVGGLSWQTSSDKLKEYF-NMFGTVTDVLIMKDPVTQRSRGFGFITF-----QEPCTVE---- 258
            .:|||.|:...:..:|.|.| |.:.:.:...|:.|.||..|:|:||:.|     |:....|
Yeast   164 SIFVGDLAPNVTESQLFELFINRYASTSHAKIVHDQVTGMSKGYGFVKFTNSDEQQLALSEMQGV 228

  Fly   259 ----KVLKV------------------PIHTLDGKKID--------------------------- 274
                :.:||                  ...:|:.:.:|
Yeast   229 FLNGRAIKVGPTSGQQQHVSGNNDYNRSSSSLNNENVDSRFLSKGQSFLSNGNNNMGFKRNHMSQ 293

  Fly   275 ---PKHATPK-NRPRQANKTKKIFVGGVSQDTSAEEVKAYFSQFG-------PVEETVMLMDQQT 328
               |....|. |.....|.| .:|:||:|...:.:|::|||..||       ||.:..
Yeast   294 FIYPVQQQPSLNHFTDPNNT-TVFIGGLSSLVTEDELRAYFQPFGTIVYVKIPVGKCC------- 350

  Fly   329 KRHRGFGFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVTPAAQLLQKRIMLGTLGVQLP 393
                  |||.:     |||                              |..:..:.|..|..:.
Yeast   351 ------GFVQY-----VDR------------------------------LSAEAAIAGMQGFPIA 374

  Fly   394 TAPGQLIGARGAGVATMNPLAMLQNPTQLLQSPAAAAAAQQAALISQNPFQVQNAAAAASIANQA 458
            .:..:|...|.|....:...|||.|..|:.|        ||..|...|...:.::...|.:...
Yeast   375 NSRVRLSWGRSAKQTALLQQAMLSNSLQVQQ--------QQPGLQQPNYGYIPSSTCEAPVLPD- 430

  Fly   459 GFGKLLTTYPQTALHSVRYAPYSIPASAATAN 490
                  .....|.|...:...||.|  .|.||
Yeast   431 ------NNVSSTMLPGCQILNYSNP--YANAN 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msi	NP_733108.2	RRM_SF	204..278	CDD:473069	24/135 (18%)
		RRM2_MSI	292..365	CDD:240769	18/79 (23%)
NAM8	NP_011954.1	RRM1_NGR1_NAM8_like	55..144	CDD:410023	23/109 (21%)
		RRM2_SECp43_like	162..241	CDD:409781	21/78 (27%)
		RRM3_NGR1_NAM8_like	312..383	CDD:409782	23/119 (19%)