Protein Alignment msi and NIFK

DIOPT Version :10

• Sequence 1: NP_733108.2
• Gene: msi / 43087
• FlyBaseID: FBgn0011666
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: NP_115766.3
• Gene: NIFK / 84365
• HGNCID: 17838
• Length: 293
• Species: Homo sapiens
• Alignment Length: 258
• Identity: 52/258 - (20%)
• Similarity: 103/258 - (39%)
• Gaps: 54/258 - (20%)

  Fly   202 PGKLFVGGLSWQTSSDKLKEYFNMFGTVTDVLIMKDPVTQRSRGFGFITFQEPCTVEKVLKVPIH 266
            ||.::|..|.......::..||:.|||||...:.:...|..|:|:.|:.|:.    |.|.|:...
Human    44 PGVVYVRHLPNLLDETQIFSYFSQFGTVTRFRLSRSKRTGNSKGYAFVEFES----EDVAKIVAE 104

  Fly   267 TLD----GKKIDPKHATPKNRPRQANKTKKIFVGGVSQD-------TSAEEVKAYFSQFGPVEET 320
            |::    |:::...|..|   |.:.:  |::|     :|       .|...||.| ::...:.:.
Human   105 TMNNYLFGERLLECHFMP---PEKVH--KELF-----KDWNIPFKQPSYPSVKRY-NRNRTLTQK 158

  Fly   321 VMLMDQQTKRHRGFGFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVTPAAQLLQKRIML 385
            :.:.::..|:.|      ...:.:..:..:..|.::..:|.|......::..|....|.:|:..:
Human   159 LRMEERFKKKER------LLRKKLAKKGIDYDFPSLILQKTESISKTNRQTSTKGQVLRKKKKKV 217

  Fly   386 -GTLGVQLPTAPGQ---------LIGARGAGVATMN------------PLAMLQNPTQLLQSP 426
             |||.....|...|         .:..|.:.||.:|            |::.::...|..|:|
Human   218 SGTLDTPEKTVDSQGPTPVCTPTFLERRKSQVAELNDDDKDDEIVFKQPISCVKEEIQETQTP 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msi	NP_733108.2	RRM_SF	204..278	CDD:473069	19/77 (25%)
		RRM2_MSI	292..365	CDD:240769	11/79 (14%)
NIFK	NP_115766.3	half-pint	2..>151	CDD:130706	31/121 (26%)
		RRM_NIFK_like	46..119	CDD:409748	19/76 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	197..239		8/41 (20%)
		Interaction with MKI67	226..269		7/42 (17%)
		hNIFK_binding	227..266	CDD:463489	6/38 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..293		3/10 (30%)