Protein Alignment msi and RBM4

DIOPT Version :10

• Sequence 1: NP_733108.2
• Gene: msi / 43087
• FlyBaseID: FBgn0011666
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: NP_002887.2
• Gene: RBM4 / 5936
• HGNCID: 9901
• Length: 364
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 93/428 - (21%)
• Similarity: 164/428 - (38%)
• Gaps: 91/428 - (21%)

  Fly   204 KLFVGGLSWQTSSDKLKEYFNMFGTVTDVLIMKDPVTQRSRGFGFITFQEPCTVEKVLKVPIHTL 268
            |||:|.|..:.:..:::..|..:|.|.:..|:|:        :||:..::....|..    |..|
Human     3 KLFIGNLPREATEQEIRSLFEQYGKVLECDIIKN--------YGFVHIEDKTAAEDA----IRNL 55

  Fly   269 DGKKIDPKHATPKNRPRQANKTK---KIFVGGVSQDTSAEEVKAYFSQFGPVEETVMLMDQQTKR 330
            ...|:   |....|.....||:|   |:.||.:|...:.:|::|.|.::|||.|..::.|
Human    56 HHYKL---HGVNINVEASKNKSKTSTKLHVGNISPTCTNKELRAKFEEYGPVIECDIVKD----- 112

  Fly   331 HRGFGFVTFEN-EDVVDRVCEIHFHTIKNKKVECKKAQPKEAVTPAAQLLQKRIMLGTLGVQLPT 394
               :.||..|. ||.|:.:     ..:.|.:.:.|:               ..:.|.|  .:|.|
Human   113 ---YAFVHMERAEDAVEAI-----RGLDNTEFQGKR---------------MHVQLST--SRLRT 152

  Fly   395 APGQLIGARGAGVATMNPLAMLQNPTQLLQSPAAAAAAQQAALISQNPFQVQNAAAAASIANQAG 459
            |||                        :..........::.....:.|  :..:...|.:..|..
Human   153 APG------------------------MGDQSGCYRCGKEGHWSKECP--IDRSGRVADLTEQYN 191

  Fly   460 --FGKLLTTYPQTALHSVRY--APYSIPASAATANAALMQAHQAQSVAAAA-HHHQQQQQQQHHH 519
              :|.:.|.|..:...|:.|  |..::.|......||  ::::|.:.|||: :::.:|...|...
Human   192 EQYGAVRTPYTMSYGDSLYYNNAYGALDAYYKRCRAA--RSYEAVAAAAASVYNYAEQTLSQLPQ 254

  Fly   520 QQQTHNA-HVAAAQQQQQSHHNAVSNPASQAHSAAAAAALAANAAN----GAGAAGAHSLAAAAQ 579
            .|.|..| |:.:........|...::.|:...:||||||.|..||:    |...:......|...
Human   255 VQNTAMASHLTSTSLDPYDRHLLPTSGAAATAAAAAAAAAAVTAASTSYYGRDRSPLRRATAPVP 319

  Fly   580 QAGLMAG----NPLNAAAAAAAAAANPAAAYSNYALAN 613
            ..|...|    :.|:.|:|||..:....|.|.....|:
Human   320 TVGEGYGYGHESELSQASAAARNSLYDMARYEREQYAD 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msi	NP_733108.2	RRM_SF	204..278	CDD:473069	16/73 (22%)
		RRM2_MSI	292..365	CDD:240769	19/73 (26%)
RBM4	NP_002887.2	RRM1_RBM4	2..68	CDD:410018	18/79 (23%)
		RRM2_RBM4	78..144	CDD:410019	20/93 (22%)
		PTZ00368	<145..>181	CDD:173561	8/63 (13%)
		ZnF_C2HC	161..176	CDD:197667	0/14 (0%)
		Interaction with TNPO3. /evidence=ECO:0000269|PubMed:12628928	196..364		41/164 (25%)