DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment msi and Rbp6

DIOPT Version :9

Sequence 1:	NP_001247303.1	Gene:	msi / 43087	FlyBaseID:	FBgn0011666	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001097631.1	Gene:	Rbp6 / 39919	FlyBaseID:	FBgn0260943	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	203/501 - (40%)
Similarity:	261/501 - (52%)	Gaps:	119/501 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 PGKLFVGGLSWQTSSDKLKEYFNMFGTVTDVLIMKDPVTQRSRGFGFITFQEPCTVEKVLKVPIH 266
            |||:|:||||||||.:.|::||..:|.:::.::||||.|:|||||||:||.:|.:|:|||....|
  Fly    28 PGKMFIGGLSWQTSPESLRDYFGRYGDISEAMVMKDPTTRRSRGFGFVTFSDPNSVDKVLTQGTH 92

  Fly   267 TLDGKKIDPKHATPKN-RPRQANKTKKIFVGGVSQDTSAEEVKAYFSQFGPVEETVMLMDQQTKR 330
            .|||||:|||.|.|:. .|:...:||||||||:|..|:.|:||:||.||||:|:.:::.|:||.|
  Fly    93 ELDGKKVDPKVAFPRRAHPKMVTRTKKIFVGGLSAPTTLEDVKSYFEQFGPIEDAMLMFDKQTNR 157

  Fly   331 HRGFGFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVTPAAQLLQKRIMLGTLGVQLPTA 395
            |||||||||::|||||:|||||||.|.||.||||||||||.:.||.  |.|....|.      :|
  Fly   158 HRGFGFVTFQSEDVVDKVCEIHFHEINNKMVECKKAQPKEVMLPAN--LAKTRAAGR------SA 214

  Fly   396 PGQLI----------GARGAGVATMNPLAMLQNPTQLLQSPAAAAAAQQAALISQNPFQVQNAAA 450
            .|:|:          .|..|..|.:.|.::          .|||:..||.....|...|.|.
  Fly   215 YGELVVWGSSHAHSTAATSAAAAGLLPSSL----------AAAASVLQQQQQQQQQQQQQQQ--- 266

  Fly   451 AASIANQAGFGKLLTTYPQTALH----------------SVRYAPYSIPASAATANAALMQAHQA 499
                ..|....:|..|:||:..|                |:||.||.:||..:.|         |
  Fly   267 ----QQQQHHQQLHHTHPQSPAHSHAHHPHTHSHSQLLGSLRYTPYPLPAHLSAA---------A 318

  Fly   500 QSVAAAAHHHQQQQQQQHHHQQQTHNAHVAAAQQQQQSHHN----------------AVSNPASQ 548
            ..||...||||||||||...|||    .|.|||||.|...:                .::|||..
  Fly   319 VVVAQQQHHHQQQQQQQQQQQQQ----QVVAAQQQHQQQQSLAQVVAAAAGAAPGLLPLANPAPP 379

  Fly   549 A-----------HSAAAAAALAANAANGAGAAGAHSLAAAAQQAGLMAGNPLNAAAAAAAAAAN- 601
            |           .:||.|.:|.|:||...|.  ...|||||..:||.|  |..|..|..|||||
  Fly   380 ATPSLLQFAAGQSNAALANSLYADAAAVVGY--KRLLAAAAVSSGLRA--PTTALGALQAAAANV 440

  Fly   602 PAAAYS----------NYALANV-----DMSSFQGVDWSTMYGMGM 632
            ||||.:          |.|||..     ::.:.||       ||.|
  Fly   441 PAAAAAAQLQQAQLRQNAALAAAHYPLSELLAMQG-------GMEM 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msi	NP_001247303.1	RRM1_hnRNPA_hnRNPD_like	205..276	CDD:240771	39/70 (56%)
msi	NP_001247303.1	RRM2_MSI	292..365	CDD:240769	49/72 (68%)
Rbp6	NP_001097631.1	RRM1_MSI	31..105	CDD:241020	41/73 (56%)
Rbp6	NP_001097631.1	RRM2_MSI	119..192	CDD:240769	49/72 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447080
Domainoid	1	1.000	82	1.000	Domainoid score	I2908
eggNOG	1	0.900	-	-		E1_KOG4205
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S972
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000417
OrthoInspector	1	1.000	-	-		mtm1160
orthoMCL	1	0.900	-	-		OOG6_101082
Panther	1	1.100	-	-	P	PTHR48032
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X310
	10	9.690