Protein Alignment msi and HNRNPA1

DIOPT Version :10

• Sequence 1: NP_733108.2
• Gene: msi / 43087
• FlyBaseID: FBgn0011666
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: NP_112420.1
• Gene: HNRNPA1 / 3178
• HGNCID: 5031
• Length: 372
• Species: Homo sapiens
• Alignment Length: 209
• Identity: 77/209 - (36%)
• Similarity: 121/209 - (57%)
• Gaps: 20/209 - (9%)

  Fly   204 KLFVGGLSWQTSSDKLKEYFNMFGTVTDVLIMKDPVTQRSRGFGFITFQEPCTVEKV---LKVPI 265
            |||:||||::|:.:.|:.:|..:||:||.::|:||.|:|||||||:|:   .|||:|   :....
Human    15 KLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTY---ATVEEVDAAMNARP 76

  Fly   266 HTLDGKKIDPKHATPK---NRPRQANKTKKIFVGGVSQDTSAEEVKAYFSQFGPVEETVMLMDQQ 327
            |.:||:.::||.|..:   .||......|||||||:.:||....::.||.|:|.:|...::.|:.
Human    77 HKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRG 141

  Fly   328 TKRHRGFGFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVTPAAQLLQKRIMLGTLGVQL 392
            :.:.|||.||||::.|.||::....:||:.....|.:||..|:.:..|:...:.|...|..|
Human   142 SGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFG--- 203

  Fly   393 PTAPGQLIGARGAG 406
                    |.||.|
Human   204 --------GGRGGG 209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msi	NP_733108.2	RRM_SF	204..278	CDD:473069	35/76 (46%)
		RRM2_MSI	292..365	CDD:240769	27/72 (38%)
HNRNPA1	NP_112420.1	Globular A domain	4..94		36/81 (44%)
		RRM1_hnRNPA1	12..92	CDD:410154	36/79 (46%)
		Globular B domain	95..185		33/89 (37%)
		RRM2_hnRNPA3	105..184	CDD:409996	30/78 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..216		9/39 (23%)
		RNA-binding RGG-box	218..240
		HnRNPA1	312..344	CDD:463312
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..372
		Nuclear targeting sequence (M9)	320..357