Protein Alignment msi and DAZAP1

DIOPT Version :10

• Sequence 1: NP_733108.2
• Gene: msi / 43087
• FlyBaseID: FBgn0011666
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: XP_011526206.1
• Gene: DAZAP1 / 26528
• HGNCID: 2683
• Length: 550
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 140/462 - (30%)
• Similarity: 197/462 - (42%)
• Gaps: 100/462 - (21%)

  Fly   165 AGAGQNNGQAAMGGSNKSGSSGRSTPSLSGG-SGS---------DPAPG-KLFVGGLSWQTSSDK 218
            ||.|     |.||    :||:.:.|.||... ||:         :..|| |||||||.|.|:.:.
Human   113 AGPG-----ACMG----AGSTPQETWSLGAPCSGTLVAVQLLPWESTPGRKLFVGGLDWSTTQET 168

  Fly   219 LKEYFNMFGTVTDVLIMKDPVTQRSRGFGFITFQEPCTVEKVLKVPIHTLDGKKIDPKHATP--- 280
            |:.||:.:|.|.|.:||||..|.:||||||:.|::|..|..||....|||||:.||||..||
Human   169 LRSYFSQYGEVVDCVIMKDKTTNQSRGFGFVKFKDPNCVGTVLASRPHTLDGRNIDPKPCTPRGM 233

  Fly   281 ---KNRPRQA---------NKTKKIFVGGVSQDTSAEEVKAYFSQFGPVEETVMLMDQQTKRHRG 333
               :.||::.         :|:.||||||:..:....|::.||.:||.|.|.||:.|.:.:|.||
Human   234 QPERTRPKEGWQKGPRSDNSKSNKIFVGGIPHNCGETELREYFKKFGVVTEVVMIYDAEKQRPRG 298

  Fly   334 FGFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVT-----PAAQLLQKRIM--------- 384
            |||:|||:|..||:...:|||.|..||||.|:|:|:::.:     |.|.....|::
Human   299 FGFITFEDEQSVDQAVNMHFHDIMGKKVEVKRAEPRDSKSQAPGQPGASQWGSRVVPNAANGWAG 363

  Fly   385 ---------LGTLGVQLPTAPGQLIGARGAGVATMNPLAMLQNPTQLLQSPAAAAAAQ-----QA 435
                     .|..|:.:|.  ||.||..|                   ..||...|..     .:
Human   364 QPPPTWQQGYGPQGMWVPA--GQAIGGYG-------------------PPPAGRGAPPPPPPFTS 407

  Fly   436 ALISQNPF---QVQNAAAAASIANQAGFGKLLTTYPQTALHSVRYAPYSIPASAATANAALMQAH 497
            .::|..|.   ..|..........|..||     |........::||..:|...||..||.:...
Human   408 YIVSTPPGGFPPPQGFPQGYGAPPQFSFG-----YGPPPPPPDQFAPPGVPPPPATPGAAPLAFP 467

  Fly   498 QAQSVAAAAHHHQQQQQQQHHHQQQTHNAHVAAAQQQQQSHHNAVSNPASQ--AHSAAAAAALAA 560
            ...|.||.........|....:.|      .|...|.........|:|:.|  ::...:......
Human   468 PPPSQAAPDMSKPPTAQPDFPYGQ------YAGYGQDLSGFGQGFSDPSQQPPSYGGPSVPGSGG 526

  Fly   561 NAANGAG 567
            ..|.|:|
Human   527 PPAGGSG 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msi	NP_733108.2	RRM_SF	204..278	CDD:473069	40/73 (55%)
		RRM2_MSI	292..365	CDD:240769	36/72 (50%)
DAZAP1	XP_011526206.1	ELAV_HUD_SF	<106..199	CDD:273741	40/94 (43%)
		RRM1_DAZAP1	154..235	CDD:409988	42/80 (53%)
		RRM2_DAZAP1	254..333	CDD:409765	39/78 (50%)