DRSC/TRiP Functional Genomics Resources

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Protein Alignment msi and Tardbp

DIOPT Version :10

Sequence 1:NP_733108.2 Gene:msi / 43087 FlyBaseID:FBgn0011666 Length:634 Species:Drosophila melanogaster
Sequence 2:NP_663531.1 Gene:Tardbp / 230908 MGIID:2387629 Length:414 Species:Mus musculus


Alignment Length:387 Identity:96/387 - (24%)
Similarity:150/387 - (38%) Gaps:90/387 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 LFVGGLSWQTSSDKLKEYFNMFGTVTDVLIMKDPVTQRSRGFGFITFQEPCTVEKVLKVPIHTLD 269
            |.|.||.|:|:...||:||:.||.|..|.:.||..|..|:||||:.|.|..|..||:. ..|.:|
Mouse   106 LIVLGLPWKTTEQDLKDYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMS-QRHMID 169

  Fly   270 GKKIDPKHATPKNRPRQANKTKKIFVGGVSQDTSAEEVKAYFSQFGPVEETVMLMDQQTKRHRGF 334
            |:..|.|....|..|.:..:::|:|||..::|.:|||::.:|.|:|.|.:..:     .|..|.|
Mouse   170 GRWCDCKLPNSKQSPDEPLRSRKVFVGRCTEDMTAEELQQFFCQYGEVVDVFI-----PKPFRAF 229

  Fly   335 GFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVTPAAQLLQKRIMLGTLGVQLPTAPGQL 399
            .||||.::.|...:|.... .||...|....|:||                              
Mouse   230 AFVTFADDKVAQSLCGEDL-IIKGISVHISNAEPK------------------------------ 263

  Fly   400 IGARGAGVATMNPLAMLQNPTQLLQSPAAAAAAQQAALISQNPFQVQNAAAAASIANQAGFGK-- 462
                             .|..:.|         :::.....||         ....||.|||.  
Mouse   264 -----------------HNSNRQL---------ERSGRFGGNP---------GGFGNQGGFGNSR 293

  Fly   463 -----LLTTYPQTALHSVRYAPYSI-PASAATANAALMQAHQAQSVAAAAHHHQQQQQQQHHHQQ 521
                 |...........:.:..:|| ||..|.|.|||..:.....:.|:         ||:....
Mouse   294 GGGAGLGNNQGGNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLAS---------QQNQSGP 349

  Fly   522 QTHNAHVAAAQQQQQSHHNAVSNPASQAHSAAAAA-ALAANAANGAGAAGAHSLAAAAQQAG 582
            ..:|....:.|::......:.:|..|.::|.|... ..|:||.:|:|..|....:..::.:|
Mouse   350 SGNNQSQGSMQREPNQAFGSGNNSYSGSNSGAPLGWGSASNAGSGSGFNGGFGSSMDSKSSG 411

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
msiNP_733108.2 RRM_SF 204..278 CDD:473069 32/72 (44%)
RRM2_MSI 292..365 CDD:240769 24/72 (33%)
TardbpNP_663531.1 TDP43_N 4..77 CDD:465833
RRM1_TDP43 105..178 CDD:409760 32/72 (44%)
RRM2_TDP43 191..261 CDD:409761 24/75 (32%)
Interaction with UBQLN2. /evidence=ECO:0000250|UniProtKB:Q13148 216..414 51/276 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..301 12/104 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..414 16/80 (20%)
Blue background indicates that the domain is not in the aligned region.

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