DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment msi and RBM24

DIOPT Version :9

Sequence 1:	NP_001247303.1	Gene:	msi / 43087	FlyBaseID:	FBgn0011666	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001137414.1	Gene:	RBM24 / 221662	HGNCID:	21539	Length:	236	Species:	Homo sapiens

Alignment Length:	337	Identity:	96/337 - (28%)
Similarity:	124/337 - (36%)	Gaps:	117/337 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 HATPKNRPRQANKTKKIFVGGVSQDTSAEEVKAYFSQFGPVEETVMLMDQQTKRHRGFGFVTFEN 341
            |.|.|:     ....||||||:...|:...::.||..||.:||.|::.|:||.:.||:||||..:
Human     2 HTTQKD-----TTYTKIFVGGLPYHTTDASLRKYFEVFGEIEEAVVITDRQTGKSRGYGFVTMAD 61

  Fly   342 EDVVDRVCEIHFHTIKNKKVECKKAQPKEAVTPAAQLLQKRIMLGTLGVQLPTAPGQLIGARGAG 406
            ....:|.|:     ..|..::.:||....|...|    :.|||          .||...     |
Human    62 RAAAERACK-----DPNPIIDGRKANVNLAYLGA----KPRIM----------QPGFAF-----G 102

  Fly   407 VATMNPLAMLQNPTQLLQSPA----AAAAAQQAALISQNPFQVQNAAAAASIANQAGFGKLLTTY 467
            |..::| |::|.|..:   ||    ..|..|...:|.    .||..|||||            |.
Human   103 VQQLHP-ALIQRPFGI---PAHYVYPQAFVQPGVVIP----HVQPTAAAAS------------TT 147

  Fly   468 PQTALHSVRYAPYSIPASAATANAALMQAHQAQSVAAAAHHHQQQQQQQHHHQQQTHNAHVAAAQ 532
            |........||.||..|:||.|.||..|...|.|.|||.:
Human   148 PYIDYTGAAYAQYSAAAAAAAAAAAYDQYPYAASPAAAGY------------------------- 187

  Fly   533 QQQQSHHNAVSNPASQAHSAAAAAALAANAANGAGAAGAHSLAAAAQQAGLMAGNPLNAAAAAAA 597
                                        ..|.|.|.|....:.|||         |..|||||||
Human   188 ----------------------------VTAGGYGYAVQQPITAAA---------PGTAAAAAAA 215

  Fly   598 AAANPAAAYSNY 609
            |||  |||:..|
Human   216 AAA--AAAFGQY 225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msi	NP_001247303.1	RRM1_hnRNPA_hnRNPD_like	205..276	CDD:240771
msi	NP_001247303.1	RRM2_MSI	292..365	CDD:240769	26/72 (36%)
RBM24	NP_001137414.1	RRM_RBM24_RBM38_like	11..86	CDD:409818	28/79 (35%)
RBM24	NP_001137414.1	Necessary for interaction with EIF4E. /evidence=ECO:0000269\|PubMed:29358667	175..199		10/76 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810