Protein Alignment msi and MSI2

DIOPT Version :9

• Sequence 1: NP_001247303.1
• Gene: msi / 43087
• FlyBaseID: FBgn0011666
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: XP_005257071.1
• Gene: MSI2 / 124540
• HGNCID: 18585
• Length: 346
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 168/453 - (37%)
• Similarity: 219/453 - (48%)
• Gaps: 139/453 - (30%)

  Fly   182 SGSSGRSTPSLSGGSGSDPA--PGKLFVGGLSWQTSSDKLKEYFNMFGTVTDVLIMKDPVTQRSR 244
            :||.|.|      ||.:|..  |||:|:||||||||.|.|::||:.||.:.:.::|:||.|:|||
Human     4 NGSQGTS------GSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSR 62

  Fly   245 GFGFITFQEPCTVEKVLKVPIHTLDGKKIDPKHATPKN-RPRQANKTKKIFVGGVSQDTSAEEVK 308
            ||||:||.:|.:|:|||..|.|.||.|.||||.|.|:. :|:...:||||||||:|.:|..|:||
Human    63 GFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVK 127

  Fly   309 AYFSQFGPVEETVMLMDQQTKRHRGFGFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVT 373
            .||.|||.||:.:::.|:.|.||||||||||||||||::|||||||.|.||.||||||||||.:.
Human   128 QYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMF 192

  Fly   374 PAAQLLQKRIMLGTLGVQLPTAPGQLIGARGAGV---ATMNPLAMLQNPTQLLQSPAAAAAAQQA 435
            |                     ||....|||...   |.|..:.||..|..:
Human   193 P---------------------PGTRGRARGLPYTMDAFMLGMGMLGYPNFV------------- 223

  Fly   436 ALISQNPFQVQNAAAAASIANQAGFGKLLTTYPQTALHSVRYAP---YSIPASAATANAALMQAH 497
                                  |.:|:   .||       .:||   |..|...|.|..
Human   224 ----------------------ATYGR---GYP-------GFAPSYGYQFPGFPAAAYG------ 250

  Fly   498 QAQSVAAAAHHHQQQQQQQHHHQQQTHNAHVAAAQQQQQSHHNAVSN---PASQAHSAAAAAALA 559
               .|||||                     ||||:....:.::|..|   |||.|.|
Human   251 ---PVAAAA---------------------VAAARGSVLNSYSAQPNFGAPASPAGS-------- 283

  Fly   560 ANAANGAGAAGAHS-------LAAAAQQAGLMAGNPLNAAAAAAAAA-----ANP--AAAYSN 608
             |.|...|..||:|       ...|:|.:|:  ||.::||:....:.     |.|  |.|::|
Human   284 -NPARPGGFPGANSPGPVADLYGPASQDSGV--GNYISAASPQPGSGFGHGIAGPLIATAFTN 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msi	NP_001247303.1	RRM1_hnRNPA_hnRNPD_like	205..276	CDD:240771	40/70 (57%)
		RRM2_MSI	292..365	CDD:240769	49/72 (68%)
MSI2	XP_005257071.1	RRM1_MSI2	17..109	CDD:410153	48/91 (53%)
		PABP-1234	<35..343	CDD:130689	148/414 (36%)
		RRM2_MSI	111..184	CDD:240769	49/72 (68%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145874
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S972
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000417
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101082
Panther	1	1.100	-	-	O	PTHR48032
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690