DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4582 and LPL

DIOPT Version :9

Sequence 1:	NP_651403.1	Gene:	CG4582 / 43086	FlyBaseID:	FBgn0039344	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	NP_000228.1	Gene:	LPL / 4023	HGNCID:	6677	Length:	475	Species:	Homo sapiens

Alignment Length:	295	Identity:	98/295 - (33%)
Similarity:	144/295 - (48%)	Gaps:	49/295 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 AASLRRSRFSPFNPTRILIHGWLGNENANMYNELLP---AYFDLRNGNYNIFTVDWGRGAIADY- 211
            |.|:....|:..:.|.::||||   ....||...:|   |....|..:.|:..|||...|...|
Human    61 AESVATCHFNHSSKTFMVIHGW---TVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYP 122

  Fly   212 ITASYRVKPVGQVLAKFVDFLHQEAGMRFEDLQLVGFSMGAHVAGLAGKHLQTGRLRMIRALDPA 276
            ::|.| .|.|||.:|:|::::.:|.....:::.|:|:|:|||.||:||. |...::..|..||||
Human   123 VSAGY-TKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGS-LTNKKVNRITGLDPA 185

  Fly   277 LPFFRYAKPKERLTAEDADYVEVLHT----SVG-SYGFDRPVGHVDFYANWGSQQPGCFWHE--- 333
            .|.|.||:...||:.:|||:|:||||    |.| |.|..:||||||.|.|.|:.||||...|
Human   186 GPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIR 250

  Fly   334 ---------------CSHWRAFMLFAESLARDQATGFLSQGCPAAEWQQ-----LTRFHRCPKDT 378
                           |||.|:..||.:||..::... .:..|.:.|..:     ..|.:||
Human   251 VIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPS-KAYRCSSKEAFEKGLCLSCRKNRC---- 310

  Fly   379 GVMQTMGGDLANVSAEFLAQRQGVYYFQTNDQPPY 413
               ..:|.::..|.    |:|....|.:|..|.||
Human   311 ---NNLGYEINKVR----AKRSSKMYLKTRSQMPY 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4582	NP_651403.1	Pancreat_lipase_like	138..409	CDD:238363	95/289 (33%)
LPL	NP_000228.1	Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:30559189	32..53
		Lipase	33..473	CDD:332983	98/295 (33%)
		Essential for determining substrate specificity. /evidence=ECO:0000269\|PubMed:7592706	243..266		2/22 (9%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000269\|PubMed:27929370	417..421
		Important for heparin binding. /evidence=ECO:0000269\|PubMed:11342582	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:26725083, ECO:0000269\|PubMed:30559189	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145312
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940