DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4582 and Lpl

DIOPT Version :9

Sequence 1:	NP_651403.1	Gene:	CG4582 / 43086	FlyBaseID:	FBgn0039344	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	NP_032535.2	Gene:	Lpl / 16956	MGIID:	96820	Length:	474	Species:	Mus musculus

Alignment Length:	295	Identity:	97/295 - (32%)
Similarity:	143/295 - (48%)	Gaps:	49/295 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 AASLRRSRFSPFNPTRILIHGWLGNENANMYNELLP---AYFDLRNGNYNIFTVDWGRGAIADY- 211
            |.|:....|:..:.|.::||||   ....||...:|   |....|..:.|:..|||...|...|
Mouse    61 ADSVSNCHFNHSSKTFVVIHGW---TVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYP 122

  Fly   212 ITASYRVKPVGQVLAKFVDFLHQEAGMRFEDLQLVGFSMGAHVAGLAGKHLQTGRLRMIRALDPA 276
            ::|.| .|.||..:|:|::::.:|.....:::.|:|:|:|||.||:||. |...::..|..||||
Mouse   123 VSAGY-TKLVGNDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGVAGS-LTNKKVNRITGLDPA 185

  Fly   277 LPFFRYAKPKERLTAEDADYVEVLHT----SVG-SYGFDRPVGHVDFYANWGSQQPGCFWHE--- 333
            .|.|.||:...||:.:|||:|:||||    |.| |.|..:||||||.|.|.|:.||||...|
Mouse   186 GPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIR 250

  Fly   334 ---------------CSHWRAFMLFAESLARDQATGFLSQGCPAAEWQQ-----LTRFHRCPKDT 378
                           |||.|:..||.:||..::... .:..|.:.|..:     ..|.:||
Mouse   251 VIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPS-KAYRCNSKEAFEKGLCLSCRKNRC---- 310

  Fly   379 GVMQTMGGDLANVSAEFLAQRQGVYYFQTNDQPPY 413
               ..:|.::..|.    |:|....|.:|..|.||
Mouse   311 ---NNLGYEINKVR----AKRSSKMYLKTRSQMPY 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4582	NP_651403.1	Pancreat_lipase_like	138..409	CDD:238363	94/289 (33%)
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53
		lipo_lipase	33..472	CDD:132274	97/295 (33%)
		Pancreat_lipase_like	37..334	CDD:238363	94/289 (33%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		2/22 (9%)
		PLAT_LPL	341..465	CDD:238856
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010