DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5112 and HER2

DIOPT Version :9

Sequence 1:	NP_651400.1	Gene:	CG5112 / 43083	FlyBaseID:	FBgn0039341	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_014021.1	Gene:	HER2 / 855338	SGDID:	S000004907	Length:	464	Species:	Saccharomyces cerevisiae

Alignment Length:	516	Identity:	113/516 - (21%)
Similarity:	185/516 - (35%)	Gaps:	137/516 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 VKAYCERIESVNRDLNAVVD-GPFPEALDQAREIDRKLDEKEYSDEDLRRLPFLGVPFSTKDSTA 134
            :|...||:.|.....|.... .|.|.:      |..|...||         ...|...|.||:..
Yeast     7 LKESIERLSSFQSKYNIFTSINPSPYS------ITNKKGTKE---------TLTGCVASIKDNIV 56

  Fly   135 VAGRLHTLGLLARKSERSTTDAECVRLMKESGAIIIATSNVPEVNKWIESRNMLIGCTNN---PY 196
            ......|......::.:|..||..|:|:|::|..|:..:|:.|........:.:.|...|   |:
Yeast    57 TKDFPTTCASHILENFKSPFDATVVKLLKQAGVHILGKTNLDEFGMGSGGVHSIRGPVINPLYPH 121

  Fly   197 DLRRSVGGSSGGEAALIAACCTGFGLGTDIGGSIRIPAFNCGIFGHKPTSGAVNMAGCTFRTGKE 261
            :.::.:||||.|.||.:|.....|.||||.|||:|:||....:.|.||:.|.::..| .....:.
Yeast   122 EDKKIMGGSSSGAAASVACDLVDFALGTDTGGSVRLPACYGSVLGFKPSYGRLSRFG-VIAYSQS 185

  Fly   262 KDTMVCAGPMSRSARDLLPMMQVLVEPSLKAKLKLDQKVDLKRLRYFYVSSNGMAQCNPINRETE 326
            .||:   |.:|:....|..:...|.:..:|....|  .|:|:.|    :..|
Yeast   186 LDTV---GILSKKINVLRKVFHTLDKYDMKDPTSL--SVELREL----IEGN------------- 228

  Fly   327 RVMYKIRKHFEAVSGKDVRHADLP------YTKLTGKMWR--------------------YWMTQ 365
               .|:|:..:....|:..|..:|      |..|..|:..                    |.::.
Yeast   229 ---KKVRRPLKVGIVKEFSHESMPIGFHRLYLSLLEKLINLGLEIYPVSIPSVKNCLPIYYTLSP 290

  Fly   366 EPANFNLLLGNG-------AELN--------PFVELF------KKILGQSDYSMAAI-------- 401
            ..|..||...:|       :||:        |....|      :.|||..:....|.
Yeast   291 AEAASNLSRYDGIRYGYRDSELDIKDGILFAPTRSKFGTEVKNRIILGNYNLCSDAFKNNFIKAE 355

  Fly   402 ---YGLID---------SVLPKEK------EKLMREATAKCKKSVQDLLGDDGVLFFHSSPRTAP 448
               ..|||         :||...|      :.|:...::|...|::|         |......:|
Yeast   356 KLRVNLIDEFDGIFRFPNVLTNSKGNPDGLDLLIVPTSSKLPGSIRD---------FEEEEAKSP 411

  Fly   449 FHYYPLVKFNDFAYFSL-FNVLHLPATQVPMGLDSKGMPLGIQVVANPNNDRLCLAVAEEL 508
            .:.|    .||  .|:: .::..||:..:|:   .:..|:|:|||....:|...|...|.:
Yeast   412 ANSY----IND--VFTVPMSLAGLPSLSMPL---KEKTPIGLQVVGQYGDDSTVLDFVESI 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5112	NP_651400.1	PRK07488	52..513	CDD:236030	113/516 (22%)
CG5112	NP_651400.1	Amidase	69..502	CDD:302749	111/508 (22%)
HER2	NP_014021.1	gatA	1..464	CDD:272925	113/516 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810