DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5112 and CG5191

DIOPT Version :9

Sequence 1:	NP_651400.1	Gene:	CG5112 / 43083	FlyBaseID:	FBgn0039341	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_650893.2	Gene:	CG5191 / 42431	FlyBaseID:	FBgn0038803	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	186/540 - (34%)
Similarity:	287/540 - (53%)	Gaps:	42/540 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 HVLDALLALVHILSDRLLE---FVLDWYLGEHKRVSGPPSLEQQTTITKS------AVELAQQIR 61
            |:.:..|.::..:..|.|.   .|..|::..:.|.:....:.::....:|      ||:||:.||
  Fly    12 HLEELWLRILGYIMRRFLRSAMIVFSWFVVPYSRYTNIKVIRRKLPPIRSHLLEIPAVDLAKLIR 76

  Fly    62 ERRQRSYDIVKAYCERIESVNRDLNAVVDGPFPEALDQAREIDRKLDEKEYSDEDLRRL-PFLGV 125
            .|:.:|.::|:||.||...||..:||:|...|.|||::|||||..:.....|.|.:..| |.||:
  Fly    77 TRKIKSEEVVEAYIERCRQVNPLINAIVQDRFEEALEEAREIDNVIAMGINSVESMEELTPLLGI 141

  Fly   126 PFSTKDSTAVAGRLHTLGLLARKSERSTTDAECVRLMKESGAIIIATSNVPEVNKWIESRNMLIG 190
            |.:.|:|.||.|..:..|.:.:..:.:.:||..|..:|.||.||:..||.||:....|:.|.:.|
  Fly   142 PVTVKESIAVKGMTNQAGRVFKTPQIAKSDAPVVEQIKRSGGIILLVSNTPELCLLWETYNNVTG 206

  Fly   191 CTNNPYDLRRSVGGSSGGEAALIAACCTGFGLGTDIGGSIRIPAFNCGIFGHKPTSGAVNMAG-- 253
            .|.|||||:|:.||||||||||:|:..:..||.:|||||.|:||...||:|||||..||:..|
  Fly   207 QTKNPYDLKRTPGGSSGGEAALLASGASLLGLTSDIGGSSRLPAMFSGIWGHKPTPYAVSFKGHH 271

  Fly   254 CTFRTGKEKDTMVCAGPMSRSARDLLPMMQVLVEPSLKAKLKLDQKVDLKRLRYFYVSSNG-MAQ 317
            .|....|..|....| ||:|.|:||..:::.:.:|: ..||.||:.:.:..:|:|::.::| ...
  Fly   272 PTSDFPKWGDFFTIA-PMTRYAKDLPLLLKCMSDPT-GPKLTLDRPISVNGIRFFFMDNDGPSGM 334

  Fly   318 CNPINRETERVMYKIRKHFEAVSGKDVRHADLPYT-------KLTGKMWR--YWMTQEPANFNLL 373
            ..|::|:....:.::...|.|   |.|....:.::       .||.|...  |..|:|
  Fly   335 MRPLSRDLHAAINRVATDFNA---KRVNIRKMKWSLDISLSAMLTMKNIETIYHKTEE------- 389

  Fly   374 LGNGAELNPFV-ELFKKILGQSDYSM-AAIYGLIDS---VLPKEKEKLMREATAKCKKSVQDLLG 433
               |.:..... |..|...|.||..: :.|:|.:.:   ::|..:.|.:.......|...:::||
  Fly   390 ---GEQPKTVCKETVKYFFGCSDSILPSVIFGHLQNFMKIIPNSRHKHLASIIEALKTEFKEMLG 451

  Fly   434 DDGVLFFHSSPRTAPFHYYPLVKFNDFAYFSLFNVLHLPATQVPMGLDSKGMPLGIQVVANPNND 498
            :|||..:.:.|.||..||....|..:..|.::||.|.||.|...:|||.:.:|:||||||||..|
  Fly   452 NDGVFLYPTFPNTAHQHYQIYHKLLEPMYMAIFNTLGLPVTNCMIGLDRRNLPMGIQVVANPGQD 516

  Fly   499 RLCLAVAEELERTFGGWVPP 518
            .|.||||.|:||.:||||.|
  Fly   517 HLSLAVAREMERRYGGWVRP 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5112	NP_651400.1	PRK07488	52..513	CDD:236030	174/484 (36%)
CG5112	NP_651400.1	Amidase	69..502	CDD:302749	158/450 (35%)
CG5191	NP_650893.2	GatA	61..537	CDD:223232	179/491 (36%)
CG5191	NP_650893.2	PRK07488	63..537	CDD:236030	178/489 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6507
eggNOG	1	0.900	-	-		E1_COG0154
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4451
Isobase	1	0.950	-	0.69812	Normalized mean entropy	S4795
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D54749at33392
OrthoFinder	1	1.000	-	-		FOG0002245
OrthoInspector	1	1.000	-	-		otm42825
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1914
SonicParanoid	1	1.000	-	-		X256
	11	10.950