DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5112 and CG7900

DIOPT Version :9

Sequence 1:	NP_651400.1	Gene:	CG5112 / 43083	FlyBaseID:	FBgn0039341	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001097707.1	Gene:	CG7900 / 40957	FlyBaseID:	FBgn0037548	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	190/548 - (34%)
Similarity:	299/548 - (54%)	Gaps:	45/548 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFWSHVLDALLALVHILSDRLLE-FVLDWYLGEHKRVSGPPSLEQQTTITKSAVELAQQIRERR 64
            |..:..::..|:.::.::...||| ||   |..:.||...||.  :...:|.|..||.::::.|:
  Fly     1 MEIFLRLIVILVKVIALIVSPLLEAFV---YRPKSKRTLIPPI--RSRLLTLSVQELRRRLQSRQ 60

  Fly    65 QRSYDIVKAYCERIESVNRDLNAVVDGPFPEALDQAREIDRKLDEKEYSDEDLRRL----PFLGV 125
            ..|.::|:.|.||||:||:.|||:::..|..||::|.|.|..:...:.:.| :.:|    |.||:
  Fly    61 LTSVELVRTYIERIEAVNKHLNALIESRFTAALEEATETDDLIASCQTAAE-VEKLFEERPLLGL 124

  Fly   126 PFSTKDSTAVAGRLHTLGLLARKSERSTTDAECVRLMKESGAIIIATSNVPEVNKWIESRNMLIG 190
            |.:.|:|.|:.|....:|.|:||:.::..|.|.|:.:|.:|||.:..|..||....||:..:|.|
  Fly   125 PVTIKESCALEGMTFAVGSLSRKNIKAEADGEAVKRLKLAGAIPLLVSATPEYCFSIETDTLLNG 189

  Fly   191 CTNNPYDLRRSVGGSSGGEAALIAACCTGFGLGTDIGGSIRIPAFNCGIFGHKPTSGAVNMAGCT 255
            ...||||..|:.|||||||.:|..|..:.||:|:|||||||||:..||||||||:.|.|::.| .
  Fly   190 RCLNPYDSERTSGGSSGGEGSLNGAGASLFGIGSDIGGSIRIPSLYCGIFGHKPSGGVVSVKG-H 253

  Fly   256 FRTGKEKDT--MVCAGPMSRSARDLLPMMQVLVEPSLKAKLKLDQKVDLKRLRYFYVSS----NG 314
            |....:.:.  .:..||::|.|.||..::||:......:||:|::.|.|.:::..|..:    ||
  Fly   254 FPNSLDPNIGHYLVEGPITRFAEDLSELLQVMAGKENSSKLRLNEPVQLNQIKVQYALAFEGING 318

  Fly   315 ---MAQCNPINRETERVMYKIRKHFEAVSGKDVRHADLPYTK------LTG----KMWRYWMTQE 366
               ||    ::::....:.|...|.:.: |.:|:...||..:      |:|    .:..|.:|.|
  Fly   319 WMHMA----VDKDITGAICKATTHLKTL-GLNVKKVKLPNLENSVEMALSGIAGQDLMDYLLTDE 378

  Fly   367 PANFNLLLGNGAELNPFVELFKKILGQSDYSM-AAIYGLI---DSVLPKEKEKLMREATAKCKKS 427
            ...     |:|.......|:.|.:.|.|.|:. |.|:.|:   .:.:.:.|.....:.|.:....
  Fly   379 NPE-----GSGKVRETVWEIVKSVRGHSKYTTNALIFELMRRTGAFMSQSKINQYMKETRELIGE 438

  Fly   428 VQDLLGDDGVLFFHSSPRTAPFHYYPLVKFNDFAYFSLFNVLHLPATQVPMGLDSKGMPLGIQVV 492
            .::||||:|||.|.:....||.|.:.::......|..:||||.||.|.|||||:.:|:|:|:.|:
  Fly   439 FENLLGDNGVLLFPTLNLPAPRHKWSILSLWGVDYTLMFNVLGLPVTHVPMGLNERGLPIGLSVI 503

  Fly   493 ANPNNDRLCLAVAEELERTFGGWVPPFP 520
            ..||.|||||.||.||||.||||.||.|
  Fly   504 GAPNQDRLCLRVAVELERAFGGWKPPVP 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5112	NP_651400.1	PRK07488	52..513	CDD:236030	170/487 (35%)
CG5112	NP_651400.1	Amidase	69..502	CDD:302749	157/459 (34%)
CG7900	NP_001097707.1	PRK07488	44..530	CDD:236030	176/497 (35%)
CG7900	NP_001097707.1	GatA	47..531	CDD:223232	176/495 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6507
eggNOG	1	0.900	-	-		E1_COG0154
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4451
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D54749at33392
OrthoFinder	1	1.000	-	-		FOG0002245
OrthoInspector	1	1.000	-	-		otm42825
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X256
	9	8.970