DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5112 and CG7910

DIOPT Version :9

Sequence 1:	NP_651400.1	Gene:	CG5112 / 43083	FlyBaseID:	FBgn0039341	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001287222.1	Gene:	CG7910 / 40956	FlyBaseID:	FBgn0037547	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	194/553 - (35%)
Similarity:	281/553 - (50%)	Gaps:	75/553 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLALV----HILSDRLLEFVLDWYLGEHKRVSGPPSLEQQTTITKSAVELAQQIRERRQRSYDIV 71
            |||.:    .:|.:::|:|||.....:...:..|       .:.||.|||..|:|.....|.::|
  Fly     7 LLAFILNAFGMLVNKILDFVLPRQKPKFSGIRNP-------LLKKSVVELVTQLRRGEITSVELV 64

  Fly    72 KAYCERIESVNRDLNAVVDGPFPEALDQAREIDRKLDEKEYSDED----LRRLPFLGVPFSTKDS 132
            .||..|::.||..|||||:..|..||..|:..|:.: ||..|:.|    ..:.|.|||||:.|:|
  Fly    65 SAYIARVQEVNPSLNAVVEDRFEAALQDAKLADQFI-EKASSEFDRVALYTKYPILGVPFTVKES 128

  Fly   133 TAVAGRLHTLGLLARKSERSTTDAECVRLMKESGAIIIATSNVPEVNKWIESRNMLIGCTNNPYD 197
            ..:.|....:|.||||:.::..|.:.|.|::.:|.|.:..|..||.....|:.|.:.|...||||
  Fly   129 CGLKGLSFAVGSLARKNMKAPQDGDVVELVRAAGGIPLLVSANPEFCMSFETSNNIQGRCLNPYD 193

  Fly   198 LRRSVGGSSGGEAALIAACCTGFGLGTDIGGSIRIPAFNCGIFGHKPTSGAVNMAGCTF---RTG 259
            |:|:..|||||||:|.....|.||:|:||.||||:||..||:||||||.|..::.| .|   .|.
  Fly   194 LQRTSAGSSGGEASLNGCGATTFGVGSDISGSIRLPALFCGVFGHKPTGGLTSVKG-HFPYSLTD 257

  Fly   260 KEKDTMVCAGPMSRSARDLLPMMQVLVEPSLKAKLKLDQKVDLKRLRYFYVSSNGMAQC--NPIN 322
            |:...|:..||::|.||| ||::..::....|.|||:.:.|.||.::.:|........|  :|:
  Fly   258 KKFSEMLQIGPITRFARD-LPLLLEIMAGDKKHKLKMSEPVALKDMKVYYAFGYSGFNCLTHPV- 320

  Fly   323 RETERVMYKIRKHF-EAVS-----GKDVRHADLPYTKLTGKMWRYWMTQEPANFNL--------L 373
                 |.:.|:... :||:     |...:..||.:.:         .:.|.|..:|        :
  Fly   321 -----VDFDIKLAITKAVTCLERGGVQSKKLDLKFLR---------NSLEIALVSLVDLKGLPSI 371

  Fly   374 LGNGAELNP-----FVELFKKILGQSDYSMAAIY--------GLIDSVLPKEKEKLMREATAKCK 425
            :...|:.:|     .||||..|:|.|.::..|:.        ||:.:...:|    .|....|.|
  Fly   372 VTQRADRDPSMRLLMVELFNSIIGHSIFTKEAMVLEVMKRFNGLMATGNMEE----YRVEAQKIK 432

  Fly   426 KSVQDLLGDDGVLF---FHSSPRTAPFHYYPLVKFNDFAYFSLFNVLHLPATQVPMGLDSKGMPL 487
            ..:..|||..|||.   ||:|  ...|| ..|:.........|||:|.||||.||||.:.:|||:
  Fly   433 SHLNQLLGTQGVLIMPTFHTS--ALCFH-TSLLNVTGIDNLLLFNILGLPATHVPMGTNQRGMPI 494

  Fly   488 GIQVVANPNNDRLCLAVAEELERTFGGWVPPFP 520
            |:||||....|:|||.||.|||..|.|||||.|
  Fly   495 GLQVVAAQYQDKLCLKVAAELEAVFHGWVPPVP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5112	NP_651400.1	PRK07488	52..513	CDD:236030	177/499 (35%)
CG5112	NP_651400.1	Amidase	69..502	CDD:302749	163/471 (35%)
CG7910	NP_001287222.1	GatA	41..527	CDD:223232	184/510 (36%)
CG7910	NP_001287222.1	PRK07488	41..525	CDD:236030	182/508 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6507
eggNOG	1	0.900	-	-		E1_COG0154
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4451
Isobase	1	0.950	-	0.69812	Normalized mean entropy	S4795
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D54749at33392
OrthoFinder	1	1.000	-	-		FOG0002245
OrthoInspector	1	1.000	-	-		otm42825
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1914
SonicParanoid	1	1.000	-	-		X256
	11	10.950