DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5112 and CG8839

DIOPT Version :9

Sequence 1:	NP_651400.1	Gene:	CG5112 / 43083	FlyBaseID:	FBgn0039341	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_610764.1	Gene:	CG8839 / 36340	FlyBaseID:	FBgn0033717	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	205/510 - (40%)
Similarity:	305/510 - (59%)	Gaps:	21/510 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LEFVLDWYLGEHKRVSGPPSLEQQTTITKSAVELAQQIRERRQRSYDIVKAYCERIESVNRDLNA 87
            :.||.....|: |..|.||..:  ..:.:||..||::||::...|..:::::..||:.||..||.
  Fly    23 IRFVFRLIYGQ-KGESVPPITD--AILLESATSLARKIRKQELSSVQVLESFIRRIKEVNPILNC 84

  Fly    88 VVDGPFPEALDQAREIDRKLDEKEYSDEDL-RRLPFLGVPFSTKDSTAVAGRLHTLGLLARKSER 151
            |||..:.:||.:|.|.|..:...:||.|:| :..||||||.:|||..:|.|.|||.||..|:..|
  Fly    85 VVDERYDQALKEAAEADALIKSGQYSTEELEKEKPFLGVPITTKDCISVKGMLHTAGLFERRDVR 149

  Fly   152 STTDAECVRLMKESGAIIIATSNVPEVNKWIESRNMLIGCTNNPYDLRRSVGGSSGGEAALIAAC 216
            :..||:.:.||:::|||.||.:||.||..|.||.|.:.|.|.|.||..|.||||||||..:.:|.
  Fly   150 AARDADAMALMRKAGAIPIALTNVSEVCMWWESNNTVHGRTRNAYDTNRIVGGSSGGEGCIQSAA 214

  Fly   217 CTGFGLGTDIGGSIRIPAFNCGIFGHKPTSGAVNMAG---CTFRTGKEKDTMVCAGPMSRSARDL 278
            .:.||||:|||||||:|||..|||||||:...|:..|   ..|  ..|:::.:..|||||.|.||
  Fly   215 ASAFGLGSDIGGSIRMPAFFNGIFGHKPSKLVVSNVGQFPAPF--SAEQNSFLGLGPMSRFAEDL 277

  Fly   279 LPMMQVLVEPSLKAKLKLDQKVDLKRLRYFYVSSNGMAQ-CNPINRETERVMYKIRKHF-EAVSG 341
            .||::::.... .|.|.||:.|||.::::||..|:|..: .:.::.:....|.::.:|. |....
  Fly   278 RPMLKIMAGEK-AALLNLDEDVDLTKMKFFYQESDGGGRLVSAVDPDLREAMNRVAQHLREKFGN 341

  Fly   342 KDVRHADLPYTKLTGKMWRYWMTQEPAN-FNLLLGN-GAELNPFVELFKKILGQSDYSMAAI-YG 403
            :.|....||:.:.:..:|...|..:..: |...||| ..::|.::||||...|.|.::...: ..
  Fly   342 QKVERIQLPHFRQSAAIWFANMRDDSGHGFAYQLGNLNHDINTYLELFKWFFGASKHTFIGLSTA 406

  Fly   404 LIDSVLPK----EKEKLMREATAKCKKSVQDLLGDDGVLFFHSSPRTAPFHYYPLVKFNDFAYFS 464
            ::||...|    :.:.|:|:.. :.::.:|.||||:|||.:.:.|..||:|..|:.:..:|||..
  Fly   407 IMDSAQCKHGSPKYDHLVRKRN-ELREELQSLLGDNGVLIYPTHPTVAPYHNEPITRPINFAYTG 470

  Fly   465 LFNVLHLPATQVPMG-LDSKGMPLGIQVVANPNNDRLCLAVAEELERTFGGWVPP 518
            :.|||..|||.||:| |.|:|:|||:|::||.|.|||||||||||||.||||..|
  Fly   471 IVNVLGFPATAVPLGKLGSEGLPLGVQIIANFNQDRLCLAVAEELERAFGGWAKP 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5112	NP_651400.1	PRK07488	52..513	CDD:236030	193/474 (41%)
CG5112	NP_651400.1	Amidase	69..502	CDD:302749	176/446 (39%)
CG8839	NP_610764.1	GatA	42..525	CDD:223232	197/488 (40%)
CG8839	NP_610764.1	PRK07488	49..520	CDD:236030	193/474 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6507
eggNOG	1	0.900	-	-		E1_COG0154
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4451
Isobase	1	0.950	-	0.69812	Normalized mean entropy	S4795
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D54749at33392
OrthoFinder	1	1.000	-	-		FOG0002245
OrthoInspector	1	1.000	-	-		otm42825
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X256
	10	9.920