DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5112 and Faahl

DIOPT Version :9

Sequence 1:	NP_651400.1	Gene:	CG5112 / 43083	FlyBaseID:	FBgn0039341	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_077046.1	Gene:	Faahl / 29347	RGDID:	6491947	Length:	579	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	129/546 - (23%)
Similarity:	216/546 - (39%)	Gaps:	118/546 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PSLEQQTTITKSAVELAQQIRERRQRSYDIVKAYCERIESVNRDLNAVVDGPFPEALDQAREIDR 105
            |.|:.:..:|...::|.|:::........:...|..:...||:..|.|.        ....:.:.
  Rat    67 PDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVT--------SYLTDCET 123

  Fly   106 KLDEKEYSDEDLRRLPFLGVPFSTKDSTAVAGRLHTLGLLARKSERSTTDAECVRLMKESGAIII 170
            :|.:..      |:....|||.|.|:..:..|...||||...:...|.:|...|:::|..||:..
  Rat   124 QLSQAP------RQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPF 182

  Fly   171 ATSNVPEVNKWIESRNMLIGCTNNPYDLRRSVGGSSGGEAALIAACCTGFGLGTDIGGSIRIPAF 235
            ..:|||:.....:..|.|.|.|.||:...:|.|||||||.|||.:..:..|||||||||||.|:.
  Rat   183 VHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSA 247

  Fly   236 NCGIFGHKPTSGAVN---MAGCTFRTGKEKDTMVCAGPMSRSARDLLPMMQVL-------VEPSL 290
            .|||.|.|||...::   :.||.:   .:....:..|||:|....|...::.|       ::|::
  Rat   248 FCGICGLKPTGNRLSKSGLKGCVY---GQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTV 309

  Fly   291 KAKLKLDQKV--DLKRLRYFYVSSNGMAQCNPINRETERVMYKIRKHFEAVSGKDVRHADLPYTK 353
             ..|...::|  ..:.||..|..::.....:|..|   |.:.:.::..||..     |..:|:..
  Rat   310 -PPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMR---RALIETKQRLEAAG-----HTLIPFLP 365

  Fly   354 --------------LTGKMWRYWMTQEPANF-NLLLGNGAELNPFVELFKKILG---QSDYSMAA 400
                          |.....|.::.....:| :..||:...:......||::|.   :..:...|
  Rat   366 NNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLA 430

  Fly   401 IYGLIDSVLPKEKEKLMR----------EATAKCKKSVQDLLGDDGVLFFHSSPRTAPFHYYPLV 455
            .:  ::|:.|:..|||.:          ...|:.|....|:|         .:|...     |.:
  Rat   431 AF--LNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVL---------LTPMLG-----PAL 479

  Fly   456 KFND-------FAYFSLFNVLHLPATQVPMGL-----------------------------DSKG 484
            ..|.       .:|..|:|.|..||..||:..                             :|.|
  Rat   480 DLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVG 544

  Fly   485 MPLGIQVVANPNNDRLCLAVAEELER 510
            :|:.:|.||.|..:.|||....|:|:
  Rat   545 LPVAVQCVALPWQEELCLRFMREVEQ 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5112	NP_651400.1	PRK07488	52..513	CDD:236030	126/535 (24%)
CG5112	NP_651400.1	Amidase	69..502	CDD:302749	120/508 (24%)
Faahl	NP_077046.1	Amidase	95..562	CDD:418511	120/508 (24%)
Faahl	NP_077046.1	Substrate binding	238..241		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I6159
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4439
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D852596at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44893
orthoMCL	1	0.900	-	-		OOG6_101248
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.770